CAS No.:59-52-9

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	intramuscular	3mg/kg (3mg/kg)	BLOOD: HEMORRHAGE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Science. Vol. 102, Pg. 601, 1945.
mouse	LD50	intramuscular	113mg/kg (113mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 223, Pg. 408, 1954.
mouse	LD50	intraperitoneal	25mg/kg (25mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	56mg/kg (56mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04985,
mouse	LD50	oral	217mg/kg (217mg/kg)		Quarterly Journal of Pharmacy & Pharmacology. Vol. 21, Pg. 364, 1948.
mouse	LD50	unreported	99mg/kg (99mg/kg)		Fukuoka Igaku Zasshi. Vol. 49, Pg. 2779, 1958.
rabbit	LD50	intramuscular	50mg/kg (50mg/kg)		Biochemical Journal. Vol. 41, Pg. 325, 1947.
rabbit	LD50	intravenous	50mg/kg (50mg/kg)		Biochemical Journal. Vol. 41, Pg. 325, 1947.
rabbit	LD50	parenteral	40mg/kg (40mg/kg)	VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION VASCULAR: REGIONAL OR GENERAL ARTERIOLAR CONSTRICTION	Annales Pharmaceutiques Francaises. Vol. 5, Pg. 172, 1947.
rabbit	LD50	unreported	80mg/kg (80mg/kg)		Fukuoka Igaku Zasshi. Vol. 49, Pg. 2779, 1958.
rat	LD50	intramuscular	87mg/kg (87mg/kg)		Toxicology and Applied Pharmacology. Vol. 36, Pg. 297, 1976.
rat	LD50	intraperitoneal	105mg/kg (105mg/kg)		Annales Pharmaceutiques Francaises. Vol. 5, Pg. 172, 1947.
rat	LD50	subcutaneous	2gm/kg (2000mg/kg)		Annales Pharmaceutiques Francaises. Vol. 5, Pg. 172, 1947.
rat	LD50	unreported	113mg/kg (113mg/kg)		Fukuoka Igaku Zasshi. Vol. 49, Pg. 2779, 1958.

Consensus Reports：

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Poison via ingestion, intramuscular, parenteral, intraperitoneal, and intravenous routes. Experimental teratogenic effects. Human systemic effects by intramuscular route: hemorrhage and dermatitis. Human blood and systemic skin effects by intramuscular route. It causes redness and swelling when applied locally to the skin, but does not produce blisters or ulcers. Intensely irritating to eyes and mucous membranes. Systemic symptoms are caused by injection. When heated to decomposition, it emits toxic fumes of SO_x. Used as an antidote to arsenic, gold, and mercury poisoning.

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-36/38 
R22:Harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R36/38:Irritating to eyes and skin.
Safety Statements: 26-36-24/25-23 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S24/25:Avoid contact with skin and eyes. 
S23:Do not breathe vapour.
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 3
F: 8-9-13-23
HazardClass: 6.1
PackingGroup: III
RTECS: UB2625000

Standards and Recommendations：

 

Analytical Methods：