CAS No.:528-74-5
Name: 3',5'-Dichloromethotrexate
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 655mg/kg (655mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
| mouse | LD50 | intravenous | 1021mg/kg (1021mg/kg) | behavioral: excitement behavioral: muscle weakness behavioral: ataxia | National Technical Information Service. Vol. PB82-172644, |
| rat | LD50 | unreported | 3130ug/kg (3.13mg/kg) | United States Patent Document. Vol. #4746662, |
Consensus Reports：
NCI Carcinogenesis Studies (ipr): Equivocal Evidence: rat; No Evidence: mouse CANCAR Cancer. 40 (1977),1935. .
SAFETY PROFILE：
Moderately toxic by intraperitoneal and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and Cl−.
Standards and Recommendations：
Analytical Methods：
Related Searches
Other Product
- -
- -
- -
- -
- -
- -
- -
- -
- -
- (4S,6R)-6-{2-[(2-hydroxy-ethyl)-(4-methoxy-benzenesulfonyl)-amino]-ethoxy}-4-isopropyl-5,6-dihydro-4H-pyran-2-carboxylic acid allyl ester
- [1,4'-Bipiperidine]-1'-carboxylic acid, 4-(1H-indol-7-yl)-, ethyl ester
- 1,3,5-Tris(4-acetamidophenyl)penta-1,5-dione
- 1,5-Bis(3-aminophenyl)-3-(4-N,N-di-methylaminophenyl)penta-1,5-dione
- 1,5-Bis(4-acetamidophenyl)-3-phenylpenta-1,5-dione
- 1,5-Bis(4-aminophenyl)-3-(4-acetamido-phenyl)penta-1,5-dione
- 1,5-Bis(4-aminophenyl)-3-phenylpenta-1,5-dione