CAS No.:1707-14-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	50mg/kg (50mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	71mg/kg (71mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 2, Pg. 589, 1960.
mouse	LD50	oral	165mg/kg (165mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 711, 1963.
mouse	LD50	subcutaneous	240mg/kg (240mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: EXCITEMENT SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Acta Pharmaceutica Suecica. Vol. 4, Pg. 37, 1967.
rabbit	LD50	intravenous	41mg/kg (41mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 286, 1972.
rat	LD50	intraperitoneal	175mg/kg (175mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 2, Pg. 589, 1960.
rat	LD50	oral	165mg/kg (165mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 711, 1963.
rat	LD50	subcutaneous	350mg/kg (350mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 2, Pg. 589, 1960.

Consensus Reports：

 

SAFETY PROFILE：

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human reproductive effects. Human teratogenic effects by ingestion: developmental abnormalities of the respiratory and gastrointestinal systems, and effects on newborn including neonatal measures or effects. When heated to decomposition it emits very toxic fumes of NO_x and HCl.

Standards and Recommendations：

 

Analytical Methods：