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CAS No.:55079-83-9

Name: Acitretin

Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 700mg/kg (700mg/kg)   United States Patent Document. Vol. #4105681,
rat LD50 oral > 4gm/kg (4000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 5033, 1982.


Consensus Reports:

 


SAFETY PROFILE:

Hazard Codes: ToxicT, DangerousN
Risk Statements: 61-36/38-50/53 
R61:May cause harm to the unborn child. 
R36/38:Irritating to eyes and skin. 
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 53-26-45-60-61-37/39 
S53:Avoid exposure - obtain special instructions before use. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S60:This material and its container must be disposed of as hazardous waste. 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets. 
S37/39:Wear suitable gloves and eye/face protection.
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: RA8460000
F: 8-10-21
An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.


Standards and Recommendations:

 


Analytical Methods:

 


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