CAS No.:79-06-1

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	150mg/kg (150mg/kg)		Toxicology and Applied Pharmacology. Vol. 6, Pg. 172, 1964.
guinea pig	LD50	subcutaneous	170mg/kg (170mg/kg)	BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Medicina del Lavoro. Industrial Medicine. Vol. 47, Pg. 192, 1956.
guinea pig	LD50	unreported	173mg/kg (173mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 38, 1978.
mammal (species unspecified)	LD50	oral	100mg/kg (100mg/kg)		Kagaku to Seibutsu. Chemistry and Biology. Vol. 17, Pg. 495, 1979.
mammal (species unspecified)	LDLo	intravenous	190mg/kg (190mg/kg)		Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 153, Pg. 895, 1911.
mouse	LD50	intraperitoneal	170mg/kg (170mg/kg)		Toxicology and Applied Pharmacology. Vol. 33, Pg. 142, 1975.
mouse	LD50	oral	107mg/kg (107mg/kg)		Archives of Toxicology. Vol. 47, Pg. 179, 1981.
mouse	LD50	unreported	156mg/kg (156mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 38, 1978.
quail	LD50	oral	186mg/kg (186mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Journal of Toxicology and Environmental Health. Vol. 7, Pg. 935, 1981.
rabbit	LD50	oral	150mg/kg (150mg/kg)		Toxicology and Applied Pharmacology. Vol. 6, Pg. 172, 1964.
rabbit	LD50	skin	1680uL/kg (1.68mL/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 115, 1990.
rabbit	LD50	unreported	280mg/kg (280mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 38, 1978.
rat	LD50	intraperitoneal	90mg/kg (90mg/kg)		Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 36, Pg. 58, 1975.
rat	LD50	oral	124mg/kg (124mg/kg)		Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 36, Pg. 58, 1975.
rat	LD50	skin	400mg/kg (400mg/kg)	BLOOD: OTHER CHANGES	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(10), Pg. 73, 1979.
rat	LD50	unreported	208mg/kg (208mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 38, 1978.

Consensus Reports：

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B MELAAD    Medicina del Lavoro. Industrial Medicine. 47 (1956),192. ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 39 (1986),p. 41 . EPA Extremely Hazardous Substances List. Community Right-To-Know List. Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Safety Information of Acrylamide (CAS NO.79-06-1):
Hazard Codes: T
Risk Statements: 45-46-20/21-25-36/38-43-48/23/24/25-62-48/20/21/22-22-24/25   
R45:May cause cancer. 
R46:May cause heritable genetic damage. 
R20/21:Harmful by inhalation and in contact with skin. 
R25 :Toxic if swallowed. 
R36/38:Irritating to eyes and skin. 
R43:May cause sensitization by skin contact. 
R48:Danger of serious damage to health by prolonged exposure. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R62:Risk of impaired fertility. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R22:Harmful if swallowed. 
R45:May cause cancer.
Safety Statements: 53-45-24-36/37/39-26-36/37
S53:Avoid exposure - obtain special instructions before use. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37:Wear suitable protective clothing and gloves.
RIDADR: UN 3426 6.1/PG 3
WGK Germany: 3
RTECS: AS3325000
F: 8-10
HazardClass: 6.1
PackingGroup: III
HS Code: 29241900

Standards and Recommendations：

OSHA PEL: TWA 0.03 mg/m³ (skin)
ACGIH TLV: Animal Carcinogen, TWA 0.03 mg/m³ (skin)
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen
NIOSH REL: TWA 0.3 mg/m³
DOT Classification:  6.1; Label: KEEP AWAY FROM FOOD

Analytical Methods：

For occupational chemical analysis use OSHA: #21.