CAS No.:89485-85-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	oral	600mg/kg (600mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
domestic animals - goat/sheep	LDLo	oral	1500mg/kg (1500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	American Journal of Veterinary Research. Vol. 32, Pg. 1229, 1971.
guinea pig	LDLo	intravenous	220mg/kg (220mg/kg)		"Handbuch der Experimentellen Pharmakologie," Heffter, A., Berlin, Verlag von Julius Springer. V.1-3, 1920-35. For publisher information, see HEPHD2.Vol. 1, Pg. 470, 1923.
guinea pig	LDLo	subcutaneous	72mg/kg (72mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
infant	LDLo	oral	2gm/kg (2000mg/kg)	CARDIAC: OTHER CHANGES	American Journal of Emergency Medicine. Vol. 6, Pg. 506, 1988.
mouse	LD50	intraperitoneal	485mg/kg (485mg/kg)		Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 256, Pg. 1043, 1963.
mouse	LD50	intravenous	358mg/kg (358mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA	Journal of Clinical Investigation. Vol. 37, Pg. 497, 1958.
mouse	LD50	oral	1300mg/kg (1300mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 257, 1990.
mouse	LDLo	subcutaneous	500mg/kg (500mg/kg)		"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 39, 1973.
rabbit	LDLo	intravenous	78mg/kg (78mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit	LDLo	oral	1gm/kg (1000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Handbuch der Experimentellen Pharmakologie," Heffter, A., Berlin, Verlag von Julius Springer. V.1-3, 1920-35. For publisher information, see HEPHD2.Vol. 1, Pg. 470, 1923.
rat	LD50	intramuscular	30mg/kg (30mg/kg)		Experimental Medicine and Surgery. Vol. 4, Pg. 223, 1946.
rat	LD50	oral	1650mg/kg (1650mg/kg)		"Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 15, 1972.
rat	LD50	unreported	550mg/kg (550mg/kg)		French Demande Patent Document. Vol. #2444025,

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