CAS No.:57-52-3

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - domestic	LDLo	intravenous	3mg/kg (3mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
guinea pig	LD50	intraperitoneal	3mg/kg (3mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: MUSCLE WEAKNESS	British Journal of Industrial Medicine. Vol. 23, Pg. 222, 1966.
guinea pig	LDLo	oral	5mg/kg (5mg/kg)		British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rabbit	LDLo	intraperitoneal	10mg/kg (10mg/kg)		British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rabbit	LDLo	intravenous	3mg/kg (3mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rabbit	LDLo	oral	10mg/kg (10mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rat	LD50	intraperitoneal	5700ug/kg (5.7mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION	British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rat	LD50	intravenous	9050ug/kg (9.05mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 242, Pg. 370, 1961.
rat	LD50	parenteral	6mg/kg (6mg/kg)	BRAIN AND COVERINGS: MENINGEAL CHANGES BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA	Biochemical Journal. Vol. 61, Pg. 406, 1955.
rat	LDLo	oral	10mg/kg (10mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION	British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rat	LDLo	subcutaneous	25mg/kg (25mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION	British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.

Consensus Reports：

 

SAFETY PROFILE：

RIDADR: UN3146
HazardClass: 6.1
PackingGroup: III
Poison by ingestion, intraperitoneal, subcutaneous, intravenous, and parenteral routes. See also TIN COMPOUNDS and SULFATES. When Bis(triethyltin) sulfate (CAS NO.57-52-3) is heated to decomposition, it emits toxic fumes of SO_x.

Standards and Recommendations：

OSHA PEL: TWA 0.1 mg(Sn)/m³ (skin)
ACGIH TLV: TWA 0.1 mg(Sn)/m³; STEL 0.2 mg(Sn)/m³ (skin).
NIOSH REL: (Organotin Compounds) TWA 0.1 mg(Sn)/m³

Analytical Methods：

For occupational chemical analysis use NIOSH: Organotin Compounds 5504.