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CAS No.:57-52-3

Name: Bis(triethyltin) sulfate

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Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - domestic LDLo intravenous 3mg/kg (3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
guinea pig LD50 intraperitoneal 3mg/kg (3mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: MUSCLE WEAKNESS
British Journal of Industrial Medicine. Vol. 23, Pg. 222, 1966.
guinea pig LDLo oral 5mg/kg (5mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rabbit LDLo intraperitoneal 10mg/kg (10mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rabbit LDLo intravenous 3mg/kg (3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rabbit LDLo oral 10mg/kg (10mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rat LD50 intraperitoneal 5700ug/kg (5.7mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION
British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rat LD50 intravenous 9050ug/kg (9.05mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 242, Pg. 370, 1961.
rat LD50 parenteral 6mg/kg (6mg/kg) BRAIN AND COVERINGS: MENINGEAL CHANGES

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: COMA
Biochemical Journal. Vol. 61, Pg. 406, 1955.
rat LDLo oral 10mg/kg (10mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION
British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.
rat LDLo subcutaneous 25mg/kg (25mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION
British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 16, 1955.


Consensus Reports:

 


SAFETY PROFILE:

RIDADR: UN3146
HazardClass: 6.1
PackingGroup: III
Poison by ingestion, intraperitoneal, subcutaneous, intravenous, and parenteral routes. See also TIN COMPOUNDS and SULFATES. When Bis(triethyltin) sulfate (CAS NO.57-52-3) is heated to decomposition, it emits toxic fumes of SOx.


Standards and Recommendations:

OSHA PEL: TWA 0.1 mg(Sn)/m3 (skin)
ACGIH TLV: TWA 0.1 mg(Sn)/m3; STEL 0.2 mg(Sn)/m3 (skin).
NIOSH REL: (Organotin Compounds) TWA 0.1 mg(Sn)/m3


Analytical Methods:

For occupational chemical analysis use NIOSH: Organotin Compounds 5504.


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