CAS No.:553-68-4
Name: Butethamine hydrochloride
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | subcutaneous | 215mg/kg (215mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Journal of Pharmacology and Experimental Therapeutics. Vol. 62, Pg. 69, 1938. |
| mouse | LD50 | intraperitoneal | 169mg/kg (169mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 483, 1958. |
| mouse | LD50 | intravenous | 36mg/kg (36mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: EXCITEMENT |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 483, 1958. |
| mouse | LD50 | subcutaneous | 449mg/kg (449mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Anesthesiology. Vol. 3, Pg. 398, 1942. |
| rabbit | LDLo | intravenous | 30mg/kg (30mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) |
Journal of Pharmacology and Experimental Therapeutics. Vol. 62, Pg. 69, 1938. |
| rat | LD50 | intraperitoneal | 182mg/kg (182mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Anesthesiology. Vol. 3, Pg. 398, 1942. |
| rat | LD50 | intravenous | 28mg/kg (28mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Anesthesiology. Vol. 3, Pg. 398, 1942. |
Consensus Reports：
SAFETY PROFILE：
A poison by intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Standards and Recommendations：
Analytical Methods：
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