CAS No.:518-75-2
Name: CITRININ
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | subcutaneous | 37mg/kg (37mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 173, 1946. |
hamster | LD50 | intraperitoneal | 66mg/kg (66mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 355, 1978. | |
hamster | LD50 | oral | 75mg/kg (75mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 355, 1978. | |
mouse | LD50 | intraperitoneal | 35mg/kg (35mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 173, 1946. |
mouse | LD50 | oral | 112mg/kg (112mg/kg) | Toxicology and Applied Pharmacology. Vol. 37, Pg. 139, 1976. | |
mouse | LD50 | subcutaneous | 73mg/kg (73mg/kg) | Food and Cosmetics Toxicology. Vol. 15, Pg. 29, 1977. | |
rabbit | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Food and Chemical Toxicology. Vol. 21, Pg. 487, 1983. |
rabbit | LD50 | intravenous | 19mg/kg (19mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 173, 1946. |
rabbit | LD50 | oral | 134mg/kg (134mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Food and Chemical Toxicology. Vol. 21, Pg. 487, 1983. |
rat | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | Pharmaceutical Bulletin. Vol. 3, Pg. 337, 1955. | |
rat | LD50 | subcutaneous | 67mg/kg (67mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BLOOD: OTHER CHANGES |
Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 173, 1946. |
Consensus Reports:
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 40 , 1986,p. 67.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210)
SAFETY PROFILE:
Poison by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. A severe skin irritant. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Citrinin (CAS NO.518-75-2):
Hazard Codes: T
Risk Statements: 23/24/25-40-36/37/38
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
40: Limited evidence of a carcinogenic effect
Safety Statements: 26-36/37/39-45-22-7/9
7: Keep container tightly closed
9: Keep container in a well-ventilated place
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Standards and Recommendations:
Analytical Methods:
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