CAS No.:64241-34-5

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	400mg/kg (400mg/kg)	cardiac: change in rate vascular: bp lowering not characterized in autonomic section kidney, ureter, and bladder: changes in blood vessels or in circulation of kidney	Journal of Cardiovascular Pharmacology. Vol. 3, Pg. 455, 1981.
dog	LD50	oral	> 2gm/kg (2000mg/kg)		Drugs of the Future. Vol. 7, Pg. 382, 1982.
mouse	LD50	intraperitoneal	362mg/kg (362mg/kg)		Drugs of the Future. Vol. 7, Pg. 382, 1982.
mouse	LD50	intravenous	162mg/kg (162mg/kg)		Drugs of the Future. Vol. 7, Pg. 382, 1982.
mouse	LD50	oral	825mg/kg (825mg/kg)		Drugs of the Future. Vol. 7, Pg. 382, 1982.
mouse	LD50	subcutaneous	1420mg/kg (1420mg/kg)	sense organs and special senses: ptosis: eye behavioral: altered sleep time (including change in righting reflex) lungs, thorax, or respiration: dyspnea	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3839, 1987.
rat	LD50	intraperitoneal	440mg/kg (440mg/kg)		Drugs of the Future. Vol. 7, Pg. 382, 1982.
rat	LD50	intravenous	269mg/kg (269mg/kg)	cardiac: change in rate vascular: bp lowering not characterized in autonomic section	Journal of Cardiovascular Pharmacology. Vol. 3, Pg. 455, 1981.
rat	LD50	oral	2060mg/kg (2060mg/kg)	cardiac: change in rate vascular: bp lowering not characterized in autonomic section	Journal of Cardiovascular Pharmacology. Vol. 3, Pg. 455, 1981.
rat	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	sense organs and special senses: ptosis: eye behavioral: altered sleep time (including change in righting reflex) liver: other changes	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3839, 1987

Consensus Reports：

 

SAFETY PROFILE：

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

Standards and Recommendations：

 

Analytical Methods：