CAS No.:133-06-2

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - domestic	LDLo	unreported	> 100mg/kg (100mg/kg)		Pesticide Manual. Vol. 9, Pg. 119, 1991.
human	LDLo	oral	1071mg/kg (1071mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 151, 1969.
mouse	LC50	inhalation	4500mg/m3/2H (4500mg/m3)		Toxicology and Applied Pharmacology. Vol. 45, Pg. 320, 1978.
mouse	LD50	intraperitoneal	30mg/kg (30mg/kg)		Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe A: Medizinische Mikrobiologie und Parasitologie. Vol. 234, Pg. 110, 1976.
mouse	LD50	oral	7gm/kg (7000mg/kg)		Toxicology and Applied Pharmacology. Vol. 45, Pg. 320, 1978.
mouse	LD50	unreported	138mg/kg (138mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(10), Pg. 24, 1973.
rabbit	LD50	unreported	740mg/kg (740mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(10), Pg. 24, 1973.
rat	LC50	inhalation	> 5700mg/m3/2H (5700mg/m3)		Toxicology and Applied Pharmacology. Vol. 45, Pg. 320, 1978.
rat	LD50	oral	9gm/kg (9000mg/kg)		Farm Chemicals Handbook. Vol. -, Pg. C59, 1991.
rat	LD50	skin	> 5gm/kg (5000mg/kg)		Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986.
rat	LD50	unreported	2650mg/kg (2650mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(10), Pg. 24, 1973.
rat	LDLo	intraperitoneal	25mg/kg (25mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SLEEP BEHAVIORAL: FLUID INTAKE	Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 168, Pg. 1173, 1974.

Consensus Reports：

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 30 , 1983,p. 295.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); Clear Evidence: mouse NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCITR* NCI-CG-TR-15 ,1977. No Evidence: rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCITR* NCI-CG-TR-15 ,1977. . EPA Genetic Toxicology Program. Community Right-To-Know List. Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Safety Information of Captan (CAS NO.133-06-2):
Hazard Codes: N ,T ,Xn ,F
Risk Statements: 23-40-41-43-50-36-20/21/22-11
R23: Toxic by inhalation. 
R40: Limited evidence of a carcinogenic effect.
R41: Risk of serious damage to the eyes. 
R43: May cause sensitization by skin contact. 
R50: Very toxic to aquatic organisms. 
R36: Irritating to eyes. 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed. 
R11: Highly flammable.
Safety Statements: 26-29-36/37/39-45-61 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S29: Do not empty into drains. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3077/9099
RTECS: GW5075000
Poison by intraperitoneal route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion and inhalation routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic and neoplastigenic data. Human mutation data reported. When heated to decomposition it emits toxic fumes of Cl⁻, SO_x, and NO_x.

Standards and Recommendations：

OSHA PEL: TWA 5 mg/m³
ACGIH TLV: TWA 5 mg/m³ (Sensitizer); Confirmed Animal Carcinogen with Unknown Revelance to Humans

Analytical Methods：