CAS No.:12663-46-6

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	subcutaneous	500mg/kg (500mg/kg)	VASCULAR: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Toxicological Sciences. Vol. 2, Pg. 349, 1977.
mouse	LD50	intraperitoneal	330ug/kg (0.33mg/kg)		Clinical Toxicology. Vol. 17, Pg. 45, 1980.
mouse	LD50	intravenous	335ug/kg (0.335mg/kg)	LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"	Food and Cosmetics Toxicology. Vol. 10, Pg. 193, 1972.
mouse	LD50	oral	6550ug/kg (6.55mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" LIVER: OTHER CHANGES	Food and Cosmetics Toxicology. Vol. 10, Pg. 193, 1972.
mouse	LD50	subcutaneous	475ug/kg (0.475mg/kg)	LIVER: OTHER CHANGES ENDOCRINE: HYPOGLYCEMIA ENDOCRINE: HYPERGLYCEMIA	Food and Cosmetics Toxicology. Vol. 10, Pg. 193, 1972.
rat	LD50	oral	5mg/kg (5mg/kg)	VASCULAR: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Toxicological Sciences. Vol. 2, Pg. 349, 1977.
rat	LD50	subcutaneous	400ug/kg (0.4mg/kg)	VASCULAR: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Toxicological Sciences. Vol. 2, Pg. 349, 1977.
rat	LDLo	intraperitoneal	50mg/kg (50mg/kg)		Applied and Environmental Microbiology. Vol. 35, Pg. 1074, 1978.

Consensus Reports：

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 , 1976,p. 139.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

SAFETY PROFILE：

A deadly poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.

Standards and Recommendations：

 

Analytical Methods：