CAS No.:59865-13-3

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	12mg/kg (12mg/kg)	VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION ENDOCRINE: ANTIDIURESIS	Journal of Hypertension. Vol. 11, Pg. 1209, 1993.
man	TDLo	oral	14286ug/kg (14.286mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Annals of Pharmacotherpy. Vol. 34, Pg. 405, 2000.
man	TDLo	oral	20mg/kg/2D-I (20mg/kg)	BEHAVIORAL: HEADACHE VASCULAR: ACUTE ARTERIAL OCCLUSION LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Lancet. Vol. 2, Pg. 1092, 1986.
man	TDLo	parenteral	20mg/kg/5D-I (20mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	American Journal of Ophthalmology. Vol. 126, Pg. 607, 1998.
man	TDLo	unreported	30mg/kg/4D-I (30mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Annals of Internal Medicine. Vol. 107, Pg. 786, 1987.
mouse	LD50	intravenous	96mg/kg (96mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.
mouse	LD50	oral	2329mg/kg (2329mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Archives of Toxicology. Vol. 53, Pg. 107, 1983.
rabbit	LD50	intravenous	10mg/kg (10mg/kg)		Toxicologic Pathology. Vol. 14, Pg. 73, 1986.
rabbit	LD50	oral	> 1gm/kg (1000mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Archives of Toxicology. Vol. 53, Pg. 107, 1983.
rat	LD50	intraperitoneal	147mg/kg (147mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.
rat	LD50	intravenous	24mg/kg (24mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.
rat	LD50	oral	1480mg/kg (1480mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Archives of Toxicology. Vol. 53, Pg. 107, 1983.
rat	LD50	subcutaneous	286mg/kg (286mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.
women	TDLo	oral	62500ug/kg/5D (62.5mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Lancet. Vol. 1, Pg. 1221, 1986.
women	TDLo	oral	1911mg/kg/91W (1911mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	British Journal of Rheumatology. Vol. 33, Pg. 90, 1994.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes of Cyclosporine (CAS NO.59865-13-3): T,Xn
Risk Statements: 45-60-22-40 
R45: May cause cancer. 
R60: May impair fertility. 
R22: Harmful if swallowed. 
R40: Limited evidence of a carcinogenic effect.
Safety Statements: 53-45-36/37-24/25-22 
S53: Avoid exposure - obtain special instructions before use. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37: Wear suitable protective clothing and gloves. 
S24/25: Avoid contact with skin and eyes. 
S22: Do not breathe dust.
WGK Germany: 3
RTECS: GZ4120000

Standards and Recommendations：

 

Analytical Methods：