CAS No.:1172-18-5

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	186mg/kg (186mg/kg)		Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse	LD50	intravenous	59100ug/kg (59.1mg/kg)		Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse	LD50	oral	596mg/kg (596mg/kg)		Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse	LD50	subcutaneous	440mg/kg (440mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rabbit	LD50	oral	568mg/kg (568mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 216, 1969.
rat	LD50	intraperitoneal	152mg/kg (152mg/kg)		Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat	LD50	intravenous	38700ug/kg (38.7mg/kg)		Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat	LD50	oral	879mg/kg (879mg/kg)		Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat	LD50	subcutaneous	859mg/kg (859mg/kg)		Drugs in Japan Vol. 6, Pg. 706, 1982.

Consensus Reports：

 

SAFETY PROFILE：

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Habituating and possibly addictive. An hypnotic and sedative. When heated to decomposition it emits very toxic fumes of F⁻, NO_x, and Cl⁻.
Safety Information of Dalmane (CAS NO.1172-18-5):
Hazard Codes: Xn
Risk Statements: 22-33 
22:  Harmful if swallowed
33:  Danger of cumulative effects
Safety Statements: 1/2-22-36-36/37/39
1:  Keep locked up 
2:  Keep out of the reach of children
22:  Do not breathe dust
36:  Wear suitable protective clothing  
37:  Wear suitable gloves  
39:  Wear eye/face protection 

Standards and Recommendations：

 

Analytical Methods：