CAS No.:17617-23-1

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	250mg/kg (250mg/kg)		Drugs of the Future. Vol. 9, Pg. 152, 1984.
human	TDLo	oral	380ug/kg (0.38mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	American Journal of Medicine. Vol. 73, Pg. 239, 1982.
mouse	LD50	intraperitoneal	540mg/kg (540mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
mouse	LD50	intravenous	59100ug/kg (59.1mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.
mouse	LD50	oral	500mg/kg (500mg/kg)		Therapie. Vol. 26, Pg. 439, 1971.
mouse	LD50	subcutaneous	3844mg/kg (3844mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rat	LD50	intraperitoneal	600mg/kg (600mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rat	LD50	intravenous	38700ug/kg (38.7mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.
rat	LD50	oral	980mg/kg (980mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rat	LD50	subcutaneous	> 3844mg/kg (3844mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.

Consensus Reports：

 

SAFETY PROFILE：

Poison by intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Caution: May be habit-forming. This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14. When heated to decomposition it emits very toxic fumes of Cl⁻, F⁻ and NO_x. See also DIAZEPAM.
Hazard Codes: Xn
Risk Statements: 22-33 
R22:Harmful if swallowed. 
R33:Danger of cumulative effects.
Safety Statements: 1/2-22-36 
S1/2:Keep locked up and out of the reach of children. 
S22:Do not breathe dust. 
S36:Wear suitable protective clothing.

Standards and Recommendations：

 

Analytical Methods：