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CAS No.:67-45-8

Name: Furazolidone

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Details Introduction

TOXICITY DATA with REFERENCE:

1.    

pic-esc 2 mg/L

    MUREAV    Mutation Research. 156 (1985),69.
2.    

cyt-hmn:lym 2 mg/L/72H

    MUREAV    Mutation Research. 59 (1979),139.
3.    

orl-man TDLo:11 mg/kg:PUL,BLD

    ARDSBL    American Review of Respiratory Disease. 105 (1972),823.
4.    

orl-rat LD50:2336 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
5.    

orl-mus LD50:1782 mg/kg

    TRSTAZ    Transactions of the Royal Society of Tropical Medicine and Hygiene. 74 (1980),43.
6.    

ipr-mus LD50:300 mg/kg

    PMDCAY    Progress in Medical Chemistry. 5 (1967),320.
7.    

orl-ckn LDLo:150 mg/kg CLDND*


Consensus Reports:

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 ,1983,p. 141.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.


SAFETY PROFILE:

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: dyspnea, respiratory depression, and eosinophilia. Experimental reproductive effects. Human mutation data reported. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: HarmfulXn
Risk Statements: 62-40
R62:Risk of impaired fertility. 
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 36-22
S36:Wear suitable protective clothing. 
S22:Do not breathe dust.
WGK Germany: 3


Standards and Recommendations:

 


Analytical Methods:

 


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