CAS No.:21187-98-4
Name: Gliclazide
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | > 1gm/kg (1000mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 17, Pg. 81, 1982. | |
| mouse | LD50 | intravenous | 295mg/kg (295mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980. |
| mouse | LD50 | oral | 3gm/kg (3000mg/kg) | Indian Drugs. Vol. 15, Pg. 161, 1978. | |
| mouse | LD50 | subcutaneous | 1034mg/kg (1034mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980. |
| rat | LD50 | intravenous | 382mg/kg (382mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980. |
| rat | LD50 | oral | 3gm/kg (3000mg/kg) | Indian Drugs. Vol. 15, Pg. 161, 1978. | |
| rat | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980. | |
| women | TDLo | oral | 9600ug/kg/24D (9.6mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED |
Internal Medicine. Vol. 33, Pg. 163, 1994. |
Consensus Reports：
SAFETY PROFILE：
Hazard Codes:
Xn,
Xi
Risk Statements:21-36/38-46-62-63
R21:Harmful in contact with skin
R36/38:Irritating to eyes and skin
R46:May cause heritable genetic damage
R62:Possible risk of impaired fertility
R63:Possible risk of harm to the unborn child
Safety Statements:25-26-36/37-53
S25:Avoid contact with eyes
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37:Wear suitable protective clothing and gloves
S53:Avoid exposure - obtain special instruction before use
WGK Germany:2
RTECS:YT4500000
Xn,XiRisk Statements:21-36/38-46-62-63
R21:Harmful in contact with skin
R36/38:Irritating to eyes and skin
R46:May cause heritable genetic damage
R62:Possible risk of impaired fertility
R63:Possible risk of harm to the unborn child
Safety Statements:25-26-36/37-53
S25:Avoid contact with eyes
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37:Wear suitable protective clothing and gloves
S53:Avoid exposure - obtain special instruction before use
WGK Germany:2
RTECS:YT4500000
Standards and Recommendations：
Analytical Methods：
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