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Current position:Home > Products > Glimepiride

CAS No.:93479-97-1

Name: Glimepiride

Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 28ug/kg/2D-I (0.028mg/kg) BLOOD: HEMORRHAGE
BLOOD: THROMBOCYTOPENIA
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Annals of Pharmacotherpy. Vol. 34, Pg. 120, 2000.
mouse LD50 unreported > 10gm/kg (10000mg/kg)   Diabetes Frontier. Vol. 3, Pg. 565, 1992.
rat LD intraperitoneal > 3950mg/kg (3950mg/kg) LIVER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 547, 1993.
rat LD oral > 10gm/kg (10000mg/kg) LIVER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 547, 1993.
rat LD50 unreported > 10gm/kg (10000mg/kg)   Diabetes Frontier. Vol. 3, Pg. 565, 1992.


Consensus Reports:

 


SAFETY PROFILE:

Hazard Codes: HarmfulXn,IrritantXi
Risk Statements: 21-36/38-46-62-63 
R21:Harmful in contact with skin. 
R36/38:Irritating to eyes and skin. 
R46:May cause heritable genetic damage. 
R62:Risk of impaired fertility. 
R63:Possible risk of harm to the unborn child.
Safety Statements: 25-26-36/37-53
S25:Avoid contact with eyes. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37:Wear suitable protective clothing and gloves. 
S53:Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: UX9363950


Standards and Recommendations:

APPEARANCE: white to yellowish crystalline powder
ASSAY (HPLC): 99.0% min
LOSS ON DRYING: 0.5% max
TOTAL IMPURITY: 1.0% max
HEAVY METALS: 20ppm max


Analytical Methods:

 


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