CAS No.:93479-97-1
Name: Glimepiride
Details Introduction
TOXICITY DATA with REFERENCE:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 28ug/kg/2D-I (0.028mg/kg) | BLOOD: HEMORRHAGE BLOOD: THROMBOCYTOPENIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Annals of Pharmacotherpy. Vol. 34, Pg. 120, 2000. |
| mouse | LD50 | unreported | > 10gm/kg (10000mg/kg) | Diabetes Frontier. Vol. 3, Pg. 565, 1992. | |
| rat | LD | intraperitoneal | > 3950mg/kg (3950mg/kg) | LIVER: OTHER CHANGES | Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 547, 1993. |
| rat | LD | oral | > 10gm/kg (10000mg/kg) | LIVER: OTHER CHANGES | Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 547, 1993. |
| rat | LD50 | unreported | > 10gm/kg (10000mg/kg) | Diabetes Frontier. Vol. 3, Pg. 565, 1992. |
Consensus Reports:
SAFETY PROFILE:
Hazard Codes:
Xn,
Xi
Risk Statements: 21-36/38-46-62-63
R21:Harmful in contact with skin.
R36/38:Irritating to eyes and skin.
R46:May cause heritable genetic damage.
R62:Risk of impaired fertility.
R63:Possible risk of harm to the unborn child.
Safety Statements: 25-26-36/37-53
S25:Avoid contact with eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
S53:Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: UX9363950
Standards and Recommendations:
APPEARANCE: white to yellowish crystalline powder
ASSAY (HPLC): 99.0% min
LOSS ON DRYING: 0.5% max
TOTAL IMPURITY: 1.0% max
HEAVY METALS: 20ppm max
Analytical Methods:
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