CAS No.:67814-76-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intramuscular	> 1800mg/kg (1800mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: NAUSEA OR VOMITING	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
dog	LD50	intravenous	720mg/kg (720mg/kg)		Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse	LD50	intramuscular	2508mg/kg (2508mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse	LD50	intraperitoneal	2244mg/kg (2244mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse	LD50	intravenous	234mg/kg (234mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse	LD50	oral	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. -, Pg. 109, 1990.
mouse	LD50	subcutaneous	3320mg/kg (3320mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
rat	LD50	intramuscular	2088mg/kg (2088mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
rat	LD50	intraperitoneal	1591mg/kg (1591mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
rat	LD50	intravenous	476mg/kg (476mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. -, Pg. 109, 1990.
rat	LD50	subcutaneous	3392mg/kg (3392mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.

Consensus Reports：

 

SAFETY PROFILE：

Moderately toxic by intraperitoneal and intramuscular route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SO_x and NO_x. See also SULFATES.

Standards and Recommendations：

 

Analytical Methods：