CAS No.:107-44-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intravenous	22ug/kg (0.022mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 50, 1961.
cat	LD50	subcutaneous	30ug/kg (0.03mg/kg)		Toxicology and Applied Pharmacology. Vol. 91, Pg. 55, 1987.
chicken	LD50	subcutaneous	16673ug/kg (16.673mg/kg)		Archives of Toxicology. Vol. 52, Pg. 71, 1983.
dog	LD50	intravenous	19ug/kg (0.019mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 50, 1961.
guinea pig	LC50	inhalation	128mg/m3/2M (128mg/m3)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1126, 1986.
guinea pig	LD50	subcutaneous	30ug/kg (0.03mg/kg)		Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
hamster	LD50	subcutaneous	95ug/kg (0.095mg/kg)		Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
human	LD50	skin	28mg/kg (28mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Science Journal. Vol. 3(4), Pg. 33, 1967.
human	TDLo	oral	2ug/kg (0.002mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
man	LDLo	intramuscular	30ug/kg (0.03mg/kg)		Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
man	TCLo	inhalation	90ug/m3 (0.09mg/m3)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE	Archives of Toxicology. Vol. 56, Pg. 201, 1985. Link to PubMed
man	TDLo	oral	102ug/kg/3D-I (0.102mg/kg)	BLOOD: OTHER CHANGES	Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
monkey	LD50	intramuscular	22300ng/kg (0.0223mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Fundamental and Applied Toxicology. Vol. 5, Pg. S169, 1985.
monkey	LD50	intravenous	20ug/kg (0.02mg/kg)		Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
mouse	LC50	inhalation	5mg/m3/30M (5mg/m3)		Deutsche Gesundheitswesen. Vol. 15, Pg. 2179, 1960.
mouse	LD50	intramuscular	164ug/kg (0.164mg/kg)		Journal of Medicinal Chemistry. Vol. 31, Pg. 807, 1988.
mouse	LD50	intraperitoneal	283ug/kg (0.283mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 172, Pg. 62, 1968.
mouse	LD50	intravenous	109ug/kg (0.109mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: INCONTINENCE	Journal of Toxicology and Environmental Health. Vol. 26, Pg. 437, 1989.
mouse	LD50	skin	1080ug/kg (1.08mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
mouse	LD50	subcutaneous	60ug/kg (0.06mg/kg)		Deutsche Gesundheitswesen. Vol. 15, Pg. 2179, 1960.
pig	LD50	intravenous	15ug/kg (0.015mg/kg)		Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
pig	LD50	skin	116mg/kg (116mg/kg)		Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
rabbit	LD50	intravenous	15ug/kg (0.015mg/kg)		Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 353, 1961.
rabbit	LD50	skin	925ug/kg (0.925mg/kg)	BEHAVIORAL: COMA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	National Technical Information Service. Vol. PB158-508,
rabbit	LD50	subcutaneous	30ug/kg (0.03mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS	Toxicology and Applied Pharmacology. Vol. 40, Pg. 109, 1977.
rat	LD50	intramuscular	108ug/kg (0.108mg/kg)		Fundamental and Applied Toxicology. Vol. 5, Pg. S84, 1985.
rat	LD50	intraperitoneal	218ug/kg (0.218mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 139, Pg. 390, 1963.
rat	LD50	intravenous	39ug/kg (0.039mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 139, Pg. 390, 1963.
rat	LD50	oral	550ug/kg (0.55mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
rat	LD50	skin	2500ug/kg (2.5mg/kg)		Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000.
rat	LD50	subcutaneous	103ug/kg (0.103mg/kg)		British Journal of Pharmacology. Vol. 39, Pg. 822, 1970.

Consensus Reports：

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

SAFETY PROFILE：

A deadly human poison by skin contact and inhalation. (A small drop on the skin can kill a man.) A deadly experimental poison by ingestion, inhalation, skin contact, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects: muscle weakness, bronchiolar constriction, nausea or vomiting, flaccid paralysis without anesthesia, miosis (pupillary constriction), cholinesterase inhibition. A “nerve gas” used as a chemical warfare agent. To fight fire, use foam, CO₂, dry chemical. When heated to decomposition or reacted with steam, it emits very toxic fumes of F⁻ and PO_x. See also PARATHION.

RIDADR 2810
HazardClass 6.1(a)
PackingGroup I

Standards and Recommendations：

 

Analytical Methods：