CAS No.:61-68-7

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intravenous	100mg/kg (100mg/kg)		Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976.
man	TDLo	oral	14285ug/kg/3D (14.285mg/kg)		British Journal of Clinical Practice. Vol. 49, Pg. 161, 1995.
man	TDLo	oral	14285ug/kg/3D (14.285mg/kg)		British Journal of Clinical Practice. Vol. 49, Pg. 161, 1995.
man	TDLo	oral	257mg/kg/12D- (257mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	British Medical Journal. Vol. 291, Pg. 661, 1985.
man	TDLo	oral	840mg/kg/6W-I (840mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	British Medical Journal. Vol. 287, Pg. 1626, 1983.
mouse	LD50	intramuscular	400mg/kg (400mg/kg)		Pharmaceutical Chemistry Journal Vol. 17, Pg. 353, 1983.
mouse	LD50	intraperitoneal	120mg/kg (120mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969.
mouse	LD50	intravenous	96mg/kg (96mg/kg)		Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1392, 1969.
mouse	LD50	oral	525mg/kg (525mg/kg)		Journal de Pharmacologie. Vol. 2, Pg. 259, 1971.
mouse	LDLo	subcutaneous	> 2gm/kg (2000mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1579, 1970.
rat	LD50	intraperitoneal	327mg/kg (327mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat	LD50	intravenous	112mg/kg (112mg/kg)		Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976.
rat	LD50	oral	740mg/kg (740mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 28, Pg. 99, 1981.
women	LDLo	oral	280mg/kg/2W-I (280mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA	Drug Safety. Vol. 6, Pg. 230, 1991.
women	TDLo	oral	20mg/kg/4D-I (20mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS	Canadian Medical Association Journal. Vol. 126, Pg. 894, 1982.
women	TDLo	oral	450mg/kg (450mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	South African Medical Journal. Vol. 67, Pg. 823, 1985.
women	TDLo	unreported	120mg/kg/4D (120mg/kg)	BEHAVIORAL: WITHDRAWAL SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Lancet. Vol. 2, Pg. 745, 1980.

Consensus Reports：

 

SAFETY PROFILE：

Safty information about Mefenamic acid (CAS NO.61-68-7) is:
Hazard Codes: Xn
Risk Statements: 22-40-20/21/22 
R22:Harmful if swallowed. 
R40:Limited evidence of a carcinogenic effect. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36
S22:Do not breathe dust. 
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: CB4550000

Standards and Recommendations：

 

Analytical Methods：