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CAS No.:3771-19-5

Name: Melipan

Details Introduction

TOXICITY DATA with REFERENCE:

1.    

dns-rat:lvr 10 mg/L

    CRNGDP    Carcinogenesis. 5 (1984),1033.
2.    

dni-mus:oth 100 µmol/L

    CNREA8    Cancer Research. 40 (1980),36.
3.    

orl-rat TDLo:39 g/kg/92W-C:CAR

    JNCIAM    Journal of the National Cancer Institute. 59 (1977),1645.
4.    

orl-mus TDLo:56 g/kg/81W-C:CAR

    CNREA8    Cancer Research. 36 (1976),1211.
5.    

orl-rat TD:33 g/kg/78W-C:ETA

    CNREA8    Cancer Research. 36 (1976),1211.
6.    

orl-rat LD50:900 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.

Consensus Reports:

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 ,1980,p. 125.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 ,1980,p. 125.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .


SAFETY PROFILE:

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by ingestion. Mutation data reported. A drug for the treatment of hypercholesterolemia or hypertriglyceridemia. When heated to decomposition it emits acrid smoke and irritating fumes.


Standards and Recommendations:

 


Analytical Methods:

 


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