CAS No.:532-03-6

TOXICITY DATA with REFERENCE：

 

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	2gm/kg (2000mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 398, 1972.
hamster	LD50	intraperitoneal	1050mg/kg (1050mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA	Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960.
hamster	LD50	oral	1410mg/kg (1410mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS	Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960.
mouse	LD50	intraperitoneal	950mg/kg (950mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 264, 1960.
mouse	LD50	intravenous	774mg/kg (774mg/kg)		Drugs in Japan Vol. 6, Pg. 836, 1982.
mouse	LD50	oral	812mg/kg (812mg/kg)		Drugs in Japan Vol. 6, Pg. 836, 1982.
mouse	LD50	subcutaneous	780mg/kg (780mg/kg)	BEHAVIORAL: ANTICONVULSANT	Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 247, 1962.
rabbit	LD50	intravenous	680mg/kg (680mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: REGIDITY BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	International Journal of Neuropharmacology. Vol. 5, Pg. 305, 1966.
rat	LD50	intraperitoneal	815mg/kg (815mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 242, 1967.
rat	LD50	oral	1320mg/kg (1320mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA	Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn
Risk Statements 22-42/43
R22: Harmful if swallowed. 
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 36
S36: Wear suitable protective clothing.
WGK: Germany 3
RTECS: TY8750000

Standards and Recommendations：

 

Analytical Methods：