CAS No.:309-36-4

TOXICITY DATA with REFERENCE：

The toxicity of Methohexital Sodium (CAS NO.309-36-4): 

1.		ivn-wmn TDLo:25 µg/kg:CVS,GIT,SKN		JOSUA9    Journal of Oral Surgery. 30 (1972),906.
2.		ivn-rat LD50:24,890 µg/kg		PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 89 (1955),292.
3.		imp-rat LD50:33 mg/kg		29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,75.
4.		ivn-mus LD50:33,600 µg/kg		OYYAA2    Oyo Yakuri. Pharmacometrics. 12 (1976),247.
5.		ivn-dog LD50:21,500 µg/kg		PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 89 (1955),292.
6.		imp-dog LD50:25 mg/kg		29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,75.
7.		ivn-rbt LD50:8640 µg/kg		PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 89 (1955),292.
8.		imp-rbt LD50:10 mg/kg		29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,75.

Consensus Reports：

 

SAFETY PROFILE：

The Fire Hazard of Methohexital Sodium (CAS NO.309-36-4): Flash point data are not available for methohexital sodium, but methohexital sodium is probably combustible. Poison by intravenous and implant routes. Human systemic effects by intravenous route: blood pressure lowering, gastrointestinal effects, and allergic dermatitis. An FDA proprietary drug. Caution: Excessive use may lead to addiction or habituation. Allergenic effects by intravenous route. When heated to decomposition it emits toxic fumes of Na₂O and NO_x. See also BARBITURATES.

Standards and Recommendations：

 

Analytical Methods：