CAS No.:12108-13-3

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LCLo	inhalation	223mg/m3/7H (223mg/m3)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.
dog	LCLo	inhalation	489mg/m3/2H (489mg/m3)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.
dog	LDLo	intravenous	10mg/kg (10mg/kg)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.
dog	LDLo	oral	620mg/kg (620mg/kg)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.
guinea pig	LCLo	inhalation	411mg/m3/7H (411mg/m3)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.
guinea pig	LD50	oral	905mg/kg (905mg/kg)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.
mouse	LC50	inhalation	58600ug/m3/4H (58.6mg/m3)		Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 20, Pg. 553, 1978.
mouse	LD50	intraperitoneal	152mg/kg (152mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 34, Pg. 183, 1978.
mouse	LD50	oral	34mg/kg (34mg/kg)		Nichidai Igaku Zasshi. Nihon University Medical Journal. Vol. 44, Pg. 173, 1985.
rabbit	LCLo	inhalation	411mg/m3/7H (411mg/m3)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.
rabbit	LD50	intravenous	6600ug/kg (6.6mg/kg)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.
rabbit	LD50	oral	95mg/kg (95mg/kg)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.
rabbit	LD50	skin	140mg/kg (140mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: CYANOSIS	American Industrial Hygiene Association Journal. Vol. 40, Pg. 164, 1979.
rat	LC50	inhalation	76mg/m3/4H (76mg/m3)	SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	American Industrial Hygiene Association Journal. Vol. 40, Pg. 164, 1979.
rat	LD50	intraperitoneal	12mg/kg (12mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: HEMORRHAGE LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA	Toxicology Letters. Vol. 39, Pg. 1, 1987.
rat	LD50	oral	8mg/kg (8mg/kg)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.
rat	LD50	skin	665mg/kg (665mg/kg)		"The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976Vol. -, Pg. -, 1976.

Consensus Reports：

EPA Extremely Hazardous Substances List. Manganese and its compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Poison by ingestion, inhalation, skin contact, intravenous, and intraperitoneal routes. A skin irritant. When heated to decomposition it emits toxic fumes of CO. See also MANGANESE COMPOUNDS and CARBONYLS.
Hazard Codes:  T 
Risk Statements:  23/24/25-40 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R40:Limited evidence of a carcinogenic effect.
Safety Statements:  23-26-36/37/39-45 
S23:Do not breathe vapour. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR:  UN 3281 6.1/PG 2
WGK Germany:  3
RTECS:  OP1450000
TSCA:  Yes
HazardClass:  6.1
PackingGroup:  II

Standards and Recommendations：

OSHA PEL: TWA 0.2 mg(Mn)/m³ (skin)
ACGIH TLV: TWA 5 mg(Mn)/m³

Analytical Methods：