Current position:Home > Products > N-MethyL-N-(m-tolyl)carbamothioic acid-(1,2,3,4-tetrahydro-1,4-methano-naphthalen-6-yl) ester
CAS No.:50838-36-3
Name: N-MethyL-N-(m-tolyl)carbamothioic acid-(1,2,3,4-tetrahydro-1,4-methano-naphthalen-6-yl) ester
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 124mg/kg (124mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING |
Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 2399, 1981. |
| dog | LD50 | oral | 5gm/kg (5000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 769, 1976. | |
| mouse | LD50 | intraperitoneal | > 420mg/kg (420mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 2399, 1981. | |
| mouse | LD50 | intravenous | 80200ug/kg (80.2mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 2399, 1981. |
| mouse | LD50 | oral | > 1800mg/kg (1800mg/kg) | Drugs in Japan Vol. -, Pg. 881, 1995. | |
| mouse | LD50 | subcutaneous | > 420mg/kg (420mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 2399, 1981. | |
| rabbit | LD50 | intravenous | 94800ug/kg (94.8mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) |
Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 2399, 1981. |
| rabbit | LD50 | oral | > 1gm/kg (1000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 2399, 1981. | |
| rat | LD50 | intraperitoneal | > 420mg/kg (420mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 2399, 1981. | |
| rat | LD50 | intravenous | 151mg/kg (151mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 2399, 1981. |
| rat | LD50 | oral | > 1800mg/kg (1800mg/kg) | Drugs in Japan Vol. -, Pg. 881, 1995. | |
| rat | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 2399, 1981. |
Consensus Reports：
SAFETY PROFILE：
N-MethyL-N-(m-tolyl)carbamothioic acid-(1,2,3,4-tetrahydro-1,4-methano-naphthalen-6-yl) ester (CAS NO.50838-36-3) is poisonous by intravenous route. Moderately toxic by ingestion. When N-MethyL-N-(m-tolyl)carbamothioic acid-(1,2,3,4-tetrahydro-1,4-methano-naphthalen-6-yl) ester (CAS NO.50838-36-3) is heated to decomposition ,it emits very toxic fumes of NOx and SOx. See also ESTERS and CARBAMATES.
Standards and Recommendations：
Analytical Methods：
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