CAS No.:3200-06-4

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	71mg/kg (71mg/kg)		Chimica Therapeutica. Vol. 3, Pg. 463, 1968.
mouse	LD50	intramuscular	696mg/kg (696mg/kg)		Chimica Therapeutica. Vol. 3, Pg. 463, 1968.
mouse	LD50	intraperitoneal	159mg/kg (159mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 1237, 1986.
mouse	LD50	intravenous	18400ug/kg (18.4mg/kg)		United States Patent Document. Vol. #4439442,
mouse	LD50	oral	365mg/kg (365mg/kg)		United States Patent Document. Vol. #4652583,
mouse	LD50	subcutaneous	547mg/kg (547mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 1237, 1986.
rabbit	LDLo	intravenous	8mg/kg (8mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 11, Pg. 103, 1985.
rabbit	LDLo	oral	1gm/kg (1000mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 11, Pg. 81, 1985.
rat	LD50	intraperitoneal	98mg/kg (98mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 1237, 1986.
rat	LD50	intravenous	11080ug/kg (11.08mg/kg)		United States Patent Document. Vol. #4439442,
rat	LD50	oral	711mg/kg (711mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 1237, 1986.
rat	LD50	subcutaneous	896mg/kg (896mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 1237, 1986.

Consensus Reports：

 

SAFETY PROFILE：

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information of Nafronyl oxalate (CAS NO.3200-06-4):
Hazard Codes: Xn,Xi
Risk Statements: 22  
22:  Harmful if swallowed 
Safety Statements: 36
36:  Wear suitable protective clothing   .

Standards and Recommendations：

 

Analytical Methods：