CAS No.:51803-78-2

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	100mg/kg/5W-I (100mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: "JAUNDICE, CHOLESTATIC" SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Journal of Hepathology. Vol. 29, Pg. 135, 1998.
mouse	LD50	intraperitoneal	216mg/kg (216mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 17, Pg. 1254, 1975.
mouse	LD50	oral	392mg/kg (392mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 17, Pg. 1254, 1975.
rat	LD50	intraperitoneal	163mg/kg (163mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 17, Pg. 1254, 1975.
rat	LD50	oral	200mg/kg (200mg/kg)		Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 34, Pg. 759, 1975.
women	TDLo	oral	2mg/kg (2mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: PROTEINURIS	Nephrology, Dialysis, Transplantation. Vol. 12, Pg. 1493, 1997.
women	TDLo	oral	84mg/kg/3W-I (84mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" BLOOD: EOSINOPHILIA	Journal of Hepathology. Vol. 29, Pg. 135, 1998.
women	TDLo	unreported	8mg/kg (8mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Allergy. Vol. 52(Suppl,

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes of Nimesulide (CAS NO.51803-78-2): Xn,Xi
Risk Statements: 22-36/37/38 
R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 36-26 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS of Nimesulide (CAS NO.51803-78-2): PB0970000

Standards and Recommendations：

 

Analytical Methods：