CAS No.:55689-65-1
Name: Oxepinac
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | > 600mg/kg (600mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978. |
mouse | LD50 | intraperitoneal | 596mg/kg (596mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978. |
mouse | LD50 | oral | 852mg/kg (852mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: PERITONITIS |
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978. |
mouse | LD50 | subcutaneous | 645mg/kg (645mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978. |
rabbit | LD50 | oral | 308mg/kg (308mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: PERITONITIS |
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978. |
rat | LD50 | intraperitoneal | 174mg/kg (174mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: PERITONITIS |
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978. |
rat | LD50 | oral | 110mg/kg (110mg/kg) | Journal of Medicinal Chemistry. Vol. 19, Pg. 941, 1976. | |
rat | LD50 | subcutaneous | 113mg/kg (113mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: PERITONITIS |
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978. |
Consensus Reports:
SAFETY PROFILE:
Poison by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
Standards and Recommendations:
Analytical Methods:
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