CAS No.:2058-46-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	100mg/kg (100mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Annals of the New York Academy of Sciences. Vol. 53, Pg. 238, 1950.
mouse	LD50	intravenous	100mg/kg (100mg/kg)		"Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 490, 1967.
mouse	LD50	oral	6696mg/kg (6696mg/kg)		Annals of the New York Academy of Sciences. Vol. 53, Pg. 238, 1950.
mouse	LD50	subcutaneous	600mg/kg (600mg/kg)		Annals of the New York Academy of Sciences. Vol. 53, Pg. 245, 1950.
rabbit	LDLo	intravenous	80mg/kg (80mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 234, 1950.
rat	LD50	intravenous	302mg/kg (302mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 234, 1950.
rat	LD50	subcutaneous	800mg/kg (800mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 711, 1959.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn,Xi
Risk Statements: 63-36-36/37/38 
R36:Irritating to eyes. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R63:Possible risk of harm to the unborn child.
Safety Statements: 36/37/39-26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

Standards and Recommendations：

 

Analytical Methods：