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CAS No.:614-39-1

Name: PROCAINAMIDE HYDROCHLORIDE

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Details Introduction

TOXICITY DATA with REFERENCE:

1.    

orl-man LDLo:857 mg/kg/60D-I:BLD

    AHJOA2    American Heart Journal. 105 (1983),1035.
2.    

orl-man TDLo:200 mg/kg/4W-I:BLD

    AIMDAP    Archives of Internal Medicine. 145 (1985),700.
3.    

orl-man TDLo:2786 mg/kg/56W-I:BLD,MSK

    AJMEAZ    American Journal of Medicine. 80 (1986),999.
4.    

ivn-rat LD50:95 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1127.
5.    

orl-mus LD50:1110 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1127.
6.    

ipr-mus LD50:325 mg/kg

    APTOA6    Acta Pharmacologica et Toxicologica. 28 (1970),17.
7.    

scu-mus LD50:800 mg/kg

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 73 (1950),236.
8.    

ivn-mus LD50:94,640 µg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),719.
9.    

ims-mus LD50:860 mg/kg

    THERAP    Therapie. 9 (1954),332.
10.    

ivn-mus LD50:150 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),112

SAFETY PROFILE:
Hazard Codes : Xn: Harmful
Risk Statements : 22: Harmful if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements : 26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection 
WGK Germany : 3
RTECS : CV2295000
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: agranulocytosis, thrombocytopenia, leukopenia, joint effects. Used as a local anesthetic. When heated to decomposition PROCAINAMIDE HYDROCHLORIDE (614-39-1) emits very toxic fumes of HCl and NOx.

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