CAS No.:614-39-1

TOXICITY DATA with REFERENCE：

1.		orl-man LDLo:857 mg/kg/60D-I:BLD		AHJOA2    American Heart Journal. 105 (1983),1035.
2.		orl-man TDLo:200 mg/kg/4W-I:BLD		AIMDAP    Archives of Internal Medicine. 145 (1985),700.
3.		orl-man TDLo:2786 mg/kg/56W-I:BLD,MSK		AJMEAZ    American Journal of Medicine. 80 (1986),999.
4.		ivn-rat LD50:95 mg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1127.
5.		orl-mus LD50:1110 mg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1127.
6.		ipr-mus LD50:325 mg/kg		APTOA6    Acta Pharmacologica et Toxicologica. 28 (1970),17.
7.		scu-mus LD50:800 mg/kg		PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 73 (1950),236.
8.		ivn-mus LD50:94,640 µg/kg		NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),719.
9.		ims-mus LD50:860 mg/kg		THERAP    Therapie. 9 (1954),332.
10.		ivn-mus LD50:150 mg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),112

SAFETY PROFILE：
Hazard Codes : Xn: Harmful
Risk Statements : 22: Harmful if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements : 26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection 
WGK Germany : 3
RTECS : CV2295000
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: agranulocytosis, thrombocytopenia, leukopenia, joint effects. Used as a local anesthetic. When heated to decomposition PROCAINAMIDE HYDROCHLORIDE (614-39-1) emits very toxic fumes of HCl and NO_x.