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CAS No.:105913-11-9

Name: Plasminogen activator

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Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 intravenous > 3300ku/kg (3300000iu/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 33, Pg. 998, 1991.
mouse LD50 intravenous 51800ug/kg (51.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,
mouse LD50 subcutaneous > 100mg/kg (100mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,
rat LD50 intravenous 30400ug/kg (30.4mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,
rat LD50 subcutaneous > 60mg/kg (60mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16(Suppl,


Consensus Reports:

 


SAFETY PROFILE:

A poison by subcutaneous and intravenous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.


Standards and Recommendations:

 


Analytical Methods:

 


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