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Current position:Home > Products > Pralidoxime mesylate

CAS No.:154-97-2

Name: Pralidoxime mesylate

Details Introduction

TOXICITY DATA with REFERENCE:

1.    

orl-hmn TDLo:52,500 mg/kg/4W-I:GIT

    AEHLAU    Archives of Environmental Health. 15 (1967),599.
2.    

ivn-hmn TDLo:45 mg/kg:CVS

    AEHLAU    Archives of Environmental Health. 15 (1967),599.
3.    

orl-rat LD50:7000 mg/kg

    CJBPAZ    Canadian Journal of Biochemistry and Physiology. 39 (1961),351.
4.    

ipr-rat LD50:262 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 13 (1958),202.
5.    

scu-rat LD50:332 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 13 (1958),202.
6.    

ivn-rat LD50:109 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 13 (1958),202.
7.    

ims-rat LD50:188 µg/kg

    BJPCBM    British Journal of Pharmacology. 39 (1970),822.
8.    

orl-mus LD50:3700 mg/kg

    CJBPAZ    Canadian Journal of Biochemistry and Physiology. 39 (1961),351.
9.    

scu-mus LD50:165 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 13 (1958),202.
10.    

ivn-mus LD50:122 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 13 (1958),202.

Consensus Reports:

 


SAFETY PROFILE:

Poison by intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Human systemic effects by ingestion: gastrointestinal changes; by intravenous route: blood pressure elevation. When heated to decomposition it emits very toxic fumes of NOx and SOx.


Standards and Recommendations:

 


Analytical Methods:

 


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