CAS No.:65-23-6

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	5143mg/kg/17W (5143mg/kg)	PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC	New England Journal of Medicine. Vol. 309, Pg. 445, 1983.
mouse	LD50	intraperitoneal	966mg/kg (966mg/kg)		Farmakologiya i Toksikologiya Vol. 40, Pg. 371, 1977.
mouse	LD50	intravenous	545mg/kg (545mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 683, 1960.
rat	LD50	intraperitoneal	1500mg/kg (1500mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Proceedings of the European Society for the Study of Drug Toxicity. Vol. 4, Pg. 179, 1964.
rat	LD50	intravenous	657mg/kg (657mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Proceedings of the Society for Experimental Biology and Medicine. Vol. 44, Pg. 147, 1940.
rat	LD50	oral	4gm/kg (4000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940.
rat	LD50	subcutaneous	3100mg/kg (3100mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940.
women	TDLo	oral	139mg/kg/5Y-I (139mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS	New England Journal of Medicine. Vol. 311, Pg. 986, 1984.
women	TDLo	oral	2100mg/kg/30D (2100mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS BEHAVIORAL: ATAXIA	Neurology. Vol. 35, Pg. 1466, 1985.
women	TDLo	oral	4800mg/kg/17W (4800mg/kg)	PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC	New England Journal of Medicine. Vol. 309, Pg. 445, 1983.

Consensus Reports：

Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: ataxia, local anesthetic, paresthesia. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes: Xi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS of Pyridoxine (CAS NO.65-23-6): UV1350000

Standards and Recommendations：

 

Analytical Methods：