CAS No.:10588-01-9

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	50mg/kg (50mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 291, 1980.
child	TDLo	oral	250mg/kg (250mg/kg)	LUNGS, THORAX, OR RESPIRATION: COUGH GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Australian Paediatric Journal. Vol. 21, Pg. 65, 1985.
frog	LDLo	intravenous	196mg/kg (196mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 62, Pg. 330, 1939.
guinea pig	LDLo	intraperitoneal	335mg/kg (335mg/kg)		Archives of Environmental Health. Vol. 11, Pg. 201, 1965.
guinea pig	LDLo	skin	335mg/kg (335mg/kg)		Archives of Environmental Health. Vol. 11, Pg. 201, 1965.
guinea pig	LDLo	subcutaneous	23mg/kg (23mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1330, 1935.
mouse	LDLo	intravenous	26200ug/kg (26.2mg/kg)		Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
rabbit	LDLo	intravenous	18400ug/kg (18.4mg/kg)		Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
rat	LD50	oral	50mg/kg (50mg/kg)	LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 22(8), Pg. 38, 1978.
rat	LDLo	subcutaneous	80mg/kg (80mg/kg)		Toxicologist. Vol. 4, Pg. 75, 1984.

Consensus Reports：

 

SAFETY PROFILE：

Confirmed carcinogen with experimental tumorigenic data. Poison by ingestion, skin contact, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: cough, nausea or vomiting, and sweating. Human mutation data reported. A caustic and irritant. A powerful oxidizer. Potentially explosive reaction with acetic anhydride, ethanol + sulfuric acid + heat, hydrazine. Violent reaction or ignition with boron + silicon (pyrotechnic), organic residues + sulfuric acid, 2-propanol + sulfuric acid, sulfuric acid + trinitrotoluene. Incompatible with hydroxylamine. When heated to decomposition it emits toxic fumes of Na₂O. See also CHROMIUM COMPOUNDS.
Hazard Codes: T+ ,N,O
Risk Statements: 45-46-60-61-8-21-25-26-34-42/43-48/23-50/53 
R45:May cause cancer. 
R46:May cause heritable genetic damage. 
R60:May impair fertility. 
R61:May cause harm to the unborn child. 
R8 :Contact with combustible material may cause fire. 
R21:Harmful in contact with skin. 
R25 :Toxic if swallowed. 
R26:Very toxic by inhalation. 
R34:Causes burns. 
R42/43:May cause sensitization by inhalation and skin contact. 
R48:Danger of serious damage to health by prolonged exposure. 
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 53-45-60-61 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53:Avoid exposure - obtain special instructions before use. 
S60:This material and its container must be disposed of as hazardous waste. 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.

Standards and Recommendations：

OSHA PEL: CL 0.1 mg/(CrO₃)/m³
ACGIH TLV: TWA 0.05 mg(Cr)/m³; Confirmed Human Carcinogen
NIOSH REL: (chromium(VI)): TWA 0.001 mg(Cr)/m³

Analytical Methods：

For occupational chemical analysis use NIOSH: Chromium Hexavalent, 7024.