CAS No.:521-78-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intramuscular	223mg/kg (223mg/kg)		Drugs in Japan Vol. -, Pg. 876, 1995.
mouse	LD50	intraperitoneal	140mg/kg (140mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse	LD50	intravenous	40mg/kg (40mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse	LD50	oral	425mg/kg (425mg/kg)		Drugs in Japan Vol. 6, Pg. 526, 1982.
mouse	LD50	subcutaneous	240mg/kg (240mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rabbit	LD50	intravenous	27mg/kg (27mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	British Journal of Pharmacology and Chemotherapy. Vol. 25, Pg. 158, 1965.
rat	LD50	intraperitoneal	150mg/kg (150mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat	LD50	intravenous	38mg/kg (38mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat	LD50	oral	800mg/kg (800mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat	LD50	subcutaneous	308mg/kg (308mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970

 

Consensus Reports：

 

SAFETY PROFILE：

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes Xn,T,F
Risk Statements 22-36/37/38-63-23/25
R22:Harmful if swallowed. 
R23/25:Toxic by inhalation and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R63:Possible risk of harm to the unborn child.
Safety Statements 26-36-45-33-24-16-7
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S33:Take precautionary measures against static discharges. 
S24:Avoid contact with skin. 
S16:Keep away from sources of ignition. 
S7:Keep container tightly closed.
RIDADR 3249
WGK Germany 3
RTECS HN9260000
HazardClass 6.1(b)
PackingGroup III

Standards and Recommendations：

 

Analytical Methods：