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Current position:Home > Products > Trimethadione

CAS No.:127-48-0

Name: Trimethadione

Details Introduction

TOXICITY DATA with REFERENCE:

The toxicity of Trimethadione (CAS NO.127-48-0):

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intraperitoneal 2gm/kg (2000mg/kg) BEHAVIORAL: SLEEP Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946.
man LDLo unreported 88mg/kg (88mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 intraperitoneal 2gm/kg (2000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 60, 1961.
mouse LD50 intravenous 2gm/kg (2000mg/kg)   Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946.
mouse LD50 oral 2100mg/kg (2100mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 377, 1973.
mouse LD50 subcutaneous > 1gm/kg (1000mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 11, Pg. 141, 1956.
mouse LD50 unreported 2170mg/kg (2170mg/kg)   United States Patent Document. Vol. #4056540,
rabbit LD50 intraperitoneal 1500mg/kg (1500mg/kg)   Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946.
rabbit LD50 intravenous 1500mg/kg (1500mg/kg)   Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946.
rat LD50 intraperitoneal 280mg/kg (280mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat LD50 intravenous 160mg/kg (160mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat LD50 oral 2140mg/kg (2140mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 138, Pg. 224, 1962.
rat LD50 subcutaneous 2gm/kg (2000mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 312, 1972.


Consensus Reports:

 


SAFETY PROFILE:

The Hazard Codes of Trimethadione (CAS NO.127-48-0):ToxicT
Risk Statements: R61:May cause harm to the unborn child. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: S53:Avoid exposure - obtain special instructions before use. S22:Do not breathe dust. S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: RQ2100000
Human poison by unspecified routes. Moderately toxic experimentally by ingestion, subcutaneous, intraperitoneal, and intravenous routes. An experimental teratogen. Human reproductive effects by ingestion: effects on newborn, including physical and other postnatal measures or effects. Human teratogenic effects by ingestion: developmental abnormalities of the craniofacial, musculoskeletal, cardiovascular, and urogenital systems. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also KETONES.


Standards and Recommendations:

 


Analytical Methods:

 


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