CAS No.:127-48-0
Name: Trimethadione
Details Introduction
TOXICITY DATA with REFERENCE:
The toxicity of Trimethadione (CAS NO.127-48-0):
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | intraperitoneal | 2gm/kg (2000mg/kg) | BEHAVIORAL: SLEEP | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946. |
man | LDLo | unreported | 88mg/kg (88mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
mouse | LD50 | intraperitoneal | 2gm/kg (2000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 60, 1961. | |
mouse | LD50 | intravenous | 2gm/kg (2000mg/kg) | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946. | |
mouse | LD50 | oral | 2100mg/kg (2100mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 377, 1973. | |
mouse | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 11, Pg. 141, 1956. | |
mouse | LD50 | unreported | 2170mg/kg (2170mg/kg) | United States Patent Document. Vol. #4056540, | |
rabbit | LD50 | intraperitoneal | 1500mg/kg (1500mg/kg) | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946. | |
rabbit | LD50 | intravenous | 1500mg/kg (1500mg/kg) | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946. | |
rat | LD50 | intraperitoneal | 280mg/kg (280mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. | |
rat | LD50 | intravenous | 160mg/kg (160mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. | |
rat | LD50 | oral | 2140mg/kg (2140mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 138, Pg. 224, 1962. | |
rat | LD50 | subcutaneous | 2gm/kg (2000mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 312, 1972. |
Consensus Reports:
SAFETY PROFILE:
The Hazard Codes of Trimethadione (CAS NO.127-48-0):T
Risk Statements: R61:May cause harm to the unborn child. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: S53:Avoid exposure - obtain special instructions before use. S22:Do not breathe dust. S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: RQ2100000
Human poison by unspecified routes. Moderately toxic experimentally by ingestion, subcutaneous, intraperitoneal, and intravenous routes. An experimental teratogen. Human reproductive effects by ingestion: effects on newborn, including physical and other postnatal measures or effects. Human teratogenic effects by ingestion: developmental abnormalities of the craniofacial, musculoskeletal, cardiovascular, and urogenital systems. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also KETONES.
Standards and Recommendations:
Analytical Methods:
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