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CAS No.:52-53-9

Name: Verapamil

Details Introduction

TOXICITY DATA with REFERENCE:

1.    

ivn-man TDLo:1429 µg/kg/5M-C:CVS,PUL,SKN

    NEJMAG    New England Journal of Medicine. 306 (1982),238.
2.    

orl-wmn TDLo:64 mg/kg

    BMJOAE    British Medical Journal. 2 (1978),1127.
3.    

orl-man TDLo:48 mg/kg/2W-I

    NEJMAG    New England Journal of Medicine. 306 (1982),612.
4.    

orl-man LDLo:83 mg/kg

    AJEMEN    American Journal of Emergency Medicine. 7 (1989),624.
5.    

ivn-man TDLo:1429 µg/kg/5M-C

    NEJMAG    New England Journal of Medicine. 306 (1982),238.
6.    

ivn-man TDLo:71 µg/kg

    AHJOA2    American Heart Journal. 111 (1986),622.
7.    

ivn-cld TDLo:250 µg/kg/5M-C

    AHJOA2    American Heart Journal. 106 (1983),145.
8.    

orl-rat LD50:163 mg/kg

    EJMCA5    European Journal of Medicinal Chemistry. Chimie Therapeutique. 25 (1990),351.
9.    

ipr-rat LD50:67 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 31 (1981),1401.
10.    

ivn-rat LD50:7250 µg/kg

    PCJOAU    Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 22 (1988),123.

Consensus Reports:ISOPTIN's consensus:
Cyanide and its compounds are on the Community Right-To-Know List.
SAFETY PROFILE:
ISOPTIN's safety:
A poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx and CN. See also NITRILES.

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