CAS No.:60525-15-7

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	80mg/kg (80mg/kg)		Acta Pharmaceutica Suecica. Vol. 20, Pg. 295, 1983.
dog	LD50	intravenous	57mg/kg (57mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1833, 1983.
dog	LD50	oral	271mg/kg (271mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1833, 1983.
man	TDLo	oral	36mg/kg (36mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	British Medical Journal. Vol. 287, Pg. 1672, 1983.
mouse	LD50	intraperitoneal	84400ug/kg (84.4mg/kg)		Acta Pharmaceutica Suecica. Vol. 20, Pg. 295, 1983.
mouse	LD50	intravenous	27700ug/kg (27.7mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1833, 1983.
mouse	LD50	oral	341mg/kg (341mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1833, 1983.
mouse	LD50	subcutaneous	154mg/kg (154mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1833, 1983.
rabbit	LD50	intravenous	50800ug/kg (50.8mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1833, 1983.
rabbit	LD50	oral	300mg/kg (300mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1833, 1983.
rat	LD50	intraperitoneal	99800ug/kg (99.8mg/kg)		Acta Pharmaceutica Suecica. Vol. 20, Pg. 295, 1983.
rat	LD50	intravenous	45800ug/kg (45.8mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1833, 1983.
rat	LD50	oral	844mg/kg (844mg/kg)		Acta Pharmaceutica Suecica. Vol. 20, Pg. 295, 1983.
rat	LD50	subcutaneous	227mg/kg (227mg/kg)		Acta Pharmaceutica Suecica. Vol. 20, Pg. 295, 1983.
women	TDLo	oral	12mg/kg/6D-I (12mg/kg)	PERIPHERAL NERVE AND SENSATION: FASCICULATIONS BEHAVIORAL: ATAXIA	Human Toxicology. Vol. 3, Pg. 141, 1984.
women	TDLo	oral	36mg/kg/9D-I (36mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"	British Medical Journal. Vol. 287, Pg. 1181, 1983.

 

Consensus Reports：

 

SAFETY PROFILE：

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: ataxia, diarrhea, fasciculations, hypermotility, jaundice. An experimental teratogen. Experimental reproductive effects. When heated to decomposition Zimeldine hydrochloride (CAS NO.60525-15-7) emits toxic fumes of Br⁻, NO_x, and HCl. See also ZIMELIDINE.

Standards and Recommendations：

 

Analytical Methods：