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zenpep


Zenpep (pancrelipase) is a combination of three enzymes (proteins): lipase, protease, and amylase. These enzymes are normally produced by the pancreas and are important in the digestion of fats, proteins, and sugars.

Zenpep is used to replace these enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts.

Zenpep may also be used following surgical removal of the pancreas.

Zenpep may also be used for purposes not listed in this medication guide.

Important information

You should not take Zenpep if you are allergic to pork proteins, or if you have a sudden onset of pancreatitis or worsening of a long-term problem with your pancreas.

Use Zenpep regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not hold the tablets or capsule contents in your mouth. Zenpep may irritate the inside of your mouth.

Do not inhale the powder from a Zenpep capsule, or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.

Before taking this medicine

You should not take Zenpep if you are allergic to pork proteins, or if you have a sudden onset of pancreatitis or worsening of a long-term problem with your pancreas.

To make sure you can safely take Zenpep, tell your doctor if you have any of these other conditions:

  • kidney disease;

  • gout; or

  • a history of blockage in your intestines.

FDA pregnancy category C. It is not known whether Zenpep will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether pancrelipase passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Zenpep?

Take Zenpep exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Zenpep should be taken with a meal or snack. Take the medicine with a full glass of water or juice.

Do not hold the capsule contents in your mouth. Zenpep may irritate the inside of your mouth.

Do not crush, chew, or break a delayed-release capsule.

However you may open the Zenpep capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow right away WITHOUT chewing. Do not save the mixture for later use. Discard the empty capsule.

Do not inhale the powder from a Zenpep capsule, or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.

Use regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store in the original container at room temperature (below 78 degrees F). Protect from moisture or high heat. Keep the bottle tightly closed when not in use. If Zenpep is exposed to temperatures between 78 and 104 degrees F, throw it away after 30 days. Do not use any capsules that have been exposed to temperatures above 104 degrees F.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Follow your doctor"s instructions about any restrictions on food, beverages, or activity.

Zenpep side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Zenpep: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe or unusual stomach pain. This could be a symptom of a rare but serious bowel disorder.

Common Zenpep side effects may include:

  • nausea or vomiting;

  • mild stomach pain or upset;

  • diarrhea or constipation;

  • bloating or gas;

  • greasy stools;

  • rectal irritation;

  • headache, dizziness;

  • cough; or

  • weight loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Zenpep?

Other drugs may interact with Zenpep, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.


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