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CAS No.:13909-02-9

Name: 1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperid yl)-1-nitrosourea

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Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 3mg/kg (3mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING
National Technical Information Service. Vol. PB282-250,
monkey LDLo intravenous 10mg/kg (10mg/kg)   National Technical Information Service. Vol. PB282-250,
mouse LD50 intraperitoneal 15210ug/kg (15.21mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 intravenous 22mg/kg (22mg/kg)   National Technical Information Service. Vol. PB282-250,
mouse LD50 oral 35700ug/kg (35.7mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)
National Technical Information Service. Vol. PB282-250,


Consensus Reports:

 


SAFETY PROFILE:

Poison by ingestion, intravenous, and intraperitoneal routes. Many N-nitroso compounds are carcinogens. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl and NOx. See also N-NITROSO COMPOUNDS.


Standards and Recommendations:

 


Analytical Methods:

 


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