CAS No.:13909-02-9
Name: 1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperid yl)-1-nitrosourea
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 3mg/kg (3mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING |
National Technical Information Service. Vol. PB282-250, |
| monkey | LDLo | intravenous | 10mg/kg (10mg/kg) | National Technical Information Service. Vol. PB282-250, | |
| mouse | LD50 | intraperitoneal | 15210ug/kg (15.21mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
| mouse | LD50 | intravenous | 22mg/kg (22mg/kg) | National Technical Information Service. Vol. PB282-250, | |
| mouse | LD50 | oral | 35700ug/kg (35.7mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) |
National Technical Information Service. Vol. PB282-250, |
Consensus Reports：
SAFETY PROFILE：
Poison by ingestion, intravenous, and intraperitoneal routes. Many N-nitroso compounds are carcinogens. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also N-NITROSO COMPOUNDS.
Standards and Recommendations：
Analytical Methods：
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