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Current position:Home > Products > 1,1,1-Trishydroxymethylpropane bicyclic phosphite

CAS No.:824-11-3

Name: 1,1,1-Trishydroxymethylpropane bicyclic phosphite

Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 2500ug/kg (2.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Toxicology. Vol. 35, Pg. 149, 1976.
chicken LD50 oral 75mg/kg (75mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Toxicology. Vol. 35, Pg. 149, 1976.
dog LD50 oral 5mg/kg (5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Toxicology. Vol. 35, Pg. 149, 1976.
guinea pig LD50 oral 20mg/kg (20mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Toxicology. Vol. 35, Pg. 149, 1976.
hamster LD50 oral 8mg/kg (8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Toxicology. Vol. 35, Pg. 149, 1976.
mouse LD50 intraperitoneal 1100ug/kg (1.1mg/kg)   Chemical & Engineering News. Vol. 52(1), Pg. 56, 1974.
mouse LD50 oral 3320ug/kg (3.32mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Toxicology. Vol. 35, Pg. 149, 1976.
mouse LD50 skin 4mg/kg (4mg/kg)   Science. Vol. 182, Pg. 1135, 1973.
mouse LDLo intravenous 1mg/kg (1mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 13, Pg. 207, 1978.
quail LD50 oral 10mg/kg (10mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Toxicology. Vol. 35, Pg. 149, 1976.
rabbit LD50 oral 50mg/kg (50mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Toxicology. Vol. 35, Pg. 149, 1976.
rat LCLo inhalation 10ppm/4H (10ppm) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Journal of Industrial Medicine. Vol. 27, Pg. 1, 1970.
rat LD50 intraperitoneal 1020ug/kg (1.02mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Toxicology. Vol. 35, Pg. 149, 1976.
rat LD50 oral 8390ug/kg (8.39mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Toxicology. Vol. 35, Pg. 149, 1976.
rat LD50 skin 929mg/kg (929mg/kg)   Archives of Toxicology. Vol. 35, Pg. 149, 1976.


Consensus Reports:

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.


SAFETY PROFILE:

Poison by ingestion, inhalation, skin contact, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of POx.Safety information of Trimethylolpropane phosphite (CAS NO.824-11-3):
Hazard Codes  VeryT+
Risk Statements 
21 Harmful in contact with skin
28 Very Toxic if swallowed
Safety Statements 
28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36/37 Wear suitable protective clothing and gloves
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR  UN 3464 6.1/PG 2
WGK Germany  3
RTECS  TY6650000
F  10-18
HazardClass  6.1(a)
PackingGroup  I


Standards and Recommendations:

 


Analytical Methods:

 


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