CAS No.:64-77-7

TOXICITY DATA with REFERENCE：

1.		sce-mus-orl 28,600 µg/kg		MUREAV    Mutation Research. 77 (1980),349.
2.		sce-ham-ipr 28,600 µg/kg		MUREAV    Mutation Research. 77 (1980),349.
3.		orl-wmn LDLo:1 g/kg:GIT:SYS		ATXKA8    Archiv fuer Toxikologie. 23 (1968),153.
4.		orl-rat LD50:2490 mg/kg		PMDCAY    Progress in Medical Chemistry. 1 (1961),187.
5.		ipr-rat LD50:860 mg/kg		FRPSAX    Farmaco, Edizione Scientifica. 12 (1957),268.
6.		ivn-rat LD50:700 mg/kg		PMDCAY    Progress in Medical Chemistry. 1 (1961),187.
7.		orl-mus LD50:490 mg/kg		IJCREE    International Journal of Crude Drug Research. 26 (1988),81.
8.		ipr-mus LD50:650 mg/kg		TXAPA9    Toxicology and Applied Pharmacology. 4 (1962),631.
9.		scu-mus LD50:980 mg/kg		NATUAS    Nature. 193 (1962),891.
10.		ivn-mus LD50:770 mg/kg		PMDCAY    Progress in Medical Chemistry. 1 (1961),187.
11.		ipr-mus LD50:700 mg/kg

Consensus Reports：

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-31 (1977). . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

SAFETY PROFILE：

Moderately toxic by ingestion and several other routes. A human teratogen. Human reproductive effects by ingestion and possibly other routes: stillbirth, developmental abnormalities of the cardiovascular (circulatory) system and urogenital system, and unspecified neonatal effects. Human systemic effects by ingestion: nausea or vomiting, hypoglycemia. Other experimental teratogenic and reproductive effects. Mutation data reported. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Safety Information about 1-Butyl-3-(4-methylphenyl)sulfonylurea (64-77-7):
Risk Statements about 1-Butyl-3-(4-methylphenyl)sulfonylurea (64-77-7):
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R40: Limited evidence of a carcinogenic effect.
R43: May cause sensitization by skin contact.
Safety Statements about 1-Butyl-3-(4-methylphenyl)sulfonylurea (64-77-7):
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 2
RTECS: YS4550000

Standards and Recommendations：

 

Analytical Methods：