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Current position:Home > Products > 2-(2-Aminoethyl)isothiourea dihydrobromide

CAS No.:56-10-0

Name: 2-(2-Aminoethyl)isothiourea dihydrobromide

Details Introduction

TOXICITY DATA with REFERENCE:

dog LD50 intraperitoneal 113mg/kg (113mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 510, 1963.
dog LD50 oral 177mg/kg (177mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 510, 1963.
guinea pig LD50 intraperitoneal 356mg/kg (356mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 218, 1960.
mouse LD50 intraperitoneal 400mg/kg (400mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 intravenous 85400ug/kg (85.4mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 218, 1960.
mouse LD50 oral 815mg/kg (815mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 218, 1960.
mouse LD50 subcutaneous 242mg/kg (242mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 576, 1957.
rabbit LD50 intraperitoneal 236mg/kg (236mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 510, 1963.
rat LD50 intraperitoneal 288mg/kg (288mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 198, 1963.
rat LD50 intravenous 85mg/kg (85mg/kg)   Casopis Lekaru Ceskych. Journal of Czech Physicians. Vol. 105, Pg. 1165, 1966.

Consensus Reports:Reported in EPA TSCA Inventory.
SAFETY PROFILE:
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits very toxic NOx, SOx, and HBr.
Hazard Codes:
    Xn: Harmful
Risk Statements about 2-β-AMINOETHYLISOTHIOUREA(56-10-0):
    R22 Harmful if swallowed.
    R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements about 2-β-AMINOETHYLISOTHIOUREA(56-10-0):
    S22 Do not breathe dust.
    S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    S36/37: Wear suitable protective clothing and gloves.

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