CAS No.:118-96-7

TOXICITY DATA with REFERENCE：

1.		skn-rbt 500 mg/24H MLD		NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD-B011-150 .
2.		mmo-sat 10 µg/plate		NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD-A080-146 .
3.		orl-hmn LDLo:28 g/kg:CNS,PUL,GIT		34ZIAG    Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,610.
4.		orl-rat LD50:795 mg/kg		JTEHD6    Journal of Toxicology and Environmental Health. 9 (1982),565.
5.		orl-mus LD50:660 mg/kg		JTEHD6    Journal of Toxicology and Environmental Health. 9 (1982),565.
6.		orl-cat LDLo:1850 mg/kg		MRCSAB    Medical Research Council, Special Report Series. 58 (1921),32.
7.		scu-cat LDLo:200 mg/kg		MRCSAB    Medical Research Council, Special Report Series. 58 (1921),32.
8.		orl-rbt LDLo:500 mg/kg		MRCSAB    Medical Research Council, Special Report Series. 58 (1921),32.
9.		scu-rbt LDLo:500 mg/kg		MRCSAB    Medical Research Council, Special Report Series. 58 (1921),32.

Consensus Reports：Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
SAFETY PROFILE：
Suspected carcinogen. Poison by subcutaneous route. Moderately toxic by ingestion. Human systemic effects by ingestion: hallucinations or distorted perceptions, cyanosis, and gastrointestinal changes. Experimental reproductive effects. Mutation data reported. A skin irritant. Has been implicated in aplastic anemia. Can cause headache, weakness, anemia, liver injury. May be absorbed through skin.

Flammable or explosive when exposed to heat or flame. Moderate explosion hazard; will detonate under strong shock. It detonates at around 240°C but can be distilled safely under reduced pressure. It is a comparatively insensitive explosive. In small quantities it will burn quietly if not confined. However, sudden heating of any quantity will cause it to detonate; the accumulation of heat when large quantities are burning will cause detonation. In other respects it is one of the most stable of all high explosives, and there are but a few restrictions for its handling. It is for this reason, from the military standpoint, that TNT is quantitatively the most used. It requires a fall of 130 cm for a 2 kg weight to detonate it. It is one of the most powerful high explosives. It can be detonated by the usual detonators and blasting caps (at least a No. 6). For full efficiency, the use of a high-velocity initiator, such as tetryl, is required. TNT is one of those explosives containing an oxygen deficiency. In other words, the addition of products that are oxygen rich can enhance its explosive power. Also mono- and dinitrotoluene may be added for reduction of the temperature of the explosion and to make the explosion flashless. Various materials are added to TNT to make what are known as permissible explosives. TNT may be regarded as the equivalent of 40% dynamite and can be used underwater. It is also used in the manufacture of a detonator fuse known as cordeau detonant. For the military, TNT finds use in all types of bursting charges, including armor-piercing types, although it is somewhat too sensitive to be ideal for this purpose and has since been replaced to a great extent by ammonium picrate. It is a relatively expensive explosive and does not compete seriously with dynamite for general commercial use.

Highly dangerous; explodes with shock or heating to 297°C. Various materials can reduce the explosive temperature: red lead (to 192°C), sodium carbonate (to 218°C), potassium hydroxide (to 192°C). Mixtures with sodium dichromate + sulfuric acid may ignite spontaneously. Reacts with nitric acid + metals (e.g., lead or iron) to form explosive products more sensitive to shock, friction, or contact with nitric or sulfuric acids. Reacts with potassium hydroxide dissolved in methanol to form explosive aci-nitro salts. Bases (e.g., sodium hydroxide, potassium iodide, tetramethyl ammonium octahydrotriborate) induce deflagration in molten TNT. Can react vigorously with reducing materials. When heated to decomposition it emits highly toxic fumes of NO_x. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and EXPLOSIVES, HIGH.

Standards and Recommendations：OSHA PEL: TWA 0.5 mg/m³ (skin)
ACGIH TLV: TWA 0.1 ppm
DFG MAK: 0.011 ppm (0.1 mg/m³); Confirmed Animal Carcinogen with Unknown Relevance to Humans
DOT Classification:  EXPLOSIVE 1.1D; Label: EXPLOSIVE 1.1D (UN 0209); DOT Class: 4.1; Label: Flammable Solid (UN 1356)
Analytical Methods：For occupational chemical analysis use OSHA: #44.