CAS No.:50-78-2

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	104mg/kg (104mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: HEMORRHAGE	Lancet. Vol. 2, Pg. 809, 1952.
child	TDLo	oral	10mg/kg/1D-I (10mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Clinical Toxicology. Vol. 18, Pg. 247, 1981.
child	TDLo	oral	39mg/kg/13D-I (39mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"	American Journal of Diseases of Children. Vol. 139, Pg. 453, 1985.
dog	LD50	intravenous	681mg/kg (681mg/kg)	BEHAVIORAL: ANALGESIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
dog	LD50	oral	700mg/kg (700mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
guinea pig	LD50	oral	1075mg/kg (1075mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.
hamster	LD50	oral	3500mg/kg (3500mg/kg)		Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
human	TDLo	oral	480mg/kg/7D-I (480mg/kg)	SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 281, 1975.
human	TDLo	oral	669mg/kg/11D (669mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED	American Journal of Hospital Pharmacy. Vol. 35, Pg. 330, 1978.
human	TDLo	oral	1050mg/kg/14D (1050mg/kg)	VASCULAR: OTHER CHANGES	Clinical Pharmacology and Therapeutics Vol. 67, Pg. 530, 2000.
human	TDLo	oral	2880mg/kg/8W (2880mg/kg)	SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 631, 1983.
infant	TDLo	oral	120mg/kg (120mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION KIDNEY, URETER, AND BLADDER: HEMATURIA	British Medical Journal. Vol. 1, Pg. 1081, 1979.
mammal (species unspecified)	LD50	oral	1750mg/kg (1750mg/kg)		Indian Journal of Medical Research. Vol. 81, Pg. 621, 1985.
man	LDLo	unreported	294mg/kg (294mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man	TDLo	oral	857mg/kg (857mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Human Toxicology. Vol. 7, Pg. 161, 1988.
man	TDLo	oral	1625mg/kg (1625mg/kg)	BEHAVIORAL: COMA	Clinical Pediatrics Vol. 24, Pg. 678, 1985.
man	TDLo	oral	13036mg/kg/5Y (13036mg/kg)	GASTROINTESTINAL: OTHER CHANGES MUSCULOSKELETAL: JOINTS SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Annals of Internal Medicine. Vol. 126, Pg. 665, 1997.
mouse	LD50	intraperitoneal	167mg/kg (167mg/kg)		United States Patent Document. Vol. #4376771,
mouse	LD50	oral	250mg/kg (250mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
mouse	LD50	subcutaneous	1020mg/kg (1020mg/kg)		Chemical and Pharmaceutical Bulletin. Vol. 28, Pg. 1237, 1980.
mouse	LD50	unreported	1350mg/kg (1350mg/kg)		United States Patent Document. Vol. #5240918,
rabbit	LD50	oral	1010mg/kg (1010mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 43, 1980.
rat	LD50	intraperitoneal	340mg/kg (340mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62, Pg. 11, 1966.
rat	LD50	oral	200mg/kg (200mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 67, 1969.
rat	LD50	rectal	790mg/kg (790mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 67, 1969.
women	TDLo	oral	480mg/kg/5D-I (480mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	New England Journal of Medicine. Vol. 296, Pg. 418, 1977.
women	TDLo	oral	525mg/kg/5D-I (525mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"	Annals of Internal Medicine. Vol. 80, Pg. 74, 1974.
women	TDLo	oral	800mg/kg (800mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" MUSCULOSKELETAL: OTHER CHANGES	American Journal of Emergency Medicine. Vol. 7, Pg. 409, 1989.
women	TDLo	rectal	4550mg/kg (4550mg/kg)	BRAIN AND COVERINGS: ENCEPHALITIS BEHAVIORAL: COMA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Annals of Pharmacotherpy. Vol. 28, Pg. 467, 1994.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn
Risk Statements: 22-36/37/38 
R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 1851
WGK Germany: 1
RTECS: VO0700000
PackingGroup: III

Standards and Recommendations：

 

Analytical Methods：