CAS No.:107-02-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LCLo	inhalation	1570mg/m3/2H (1570mg/m3)		Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.
cat	LDLo	intravenous	15mg/kg (15mg/kg)	BLOOD: OTHER CHANGES	Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 275, 1952.
child	TCLo	inhalation	300ppb/2H (0.3ppm)	LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Nouvelle Presse Medicale. Vol. 8, Pg. 2469, 1979.
guinea pig	LCLo	inhalation	24mg/m3/6H (24mg/m3)	LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	British Medical Journal. Vol. 2, Pg. 913, 1956.
guinea pig	LDLo	subcutaneous	178ug/kg (0.178mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 43, Pg. 351, 1900.
hamster	LCLo	inhalation	1000ppm/10M (1000ppm)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 19, Pg. 367, 1977.
human	LCLo	inhalation	5500ppb (5.5ppm)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 73, 1969.
human	LCLo	inhalation	153ppm/10M (153ppm)		National Technical Information Service. Vol. PB214-270,
mammal (species unspecified)	LD50	unreported	45mg/kg (45mg/kg)		"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 111, 1971.
mammal (species unspecified)	LDLo	oral	10mg/kg (10mg/kg)		American Journal of Hygiene. Vol. 29, Pg. 32, 1939.
man	TCLo	inhalation	1ppm (1ppm)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	British Medical Journal. Vol. 2, Pg. 913, 1956.
mouse	LC50	inhalation	66ppm/6H (66ppm)		Internationales Archiv fuer Arbeitsmedizin. Vol. 26, Pg. 281, 1970.
mouse	LD50	intraperitoneal	9008ug/kg (9.008mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	oral	13900ug/kg (13.9mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	National Technical Information Service. Vol. OTS0533812,
mouse	LD50	subcutaneous	30mg/kg (30mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC LIVER: FATTY LIVER DEGERATION	Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.
rabbit	LCLo	inhalation	24mg/m3/6H (24mg/m3)	LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	British Medical Journal. Vol. 2, Pg. 913, 1956.
rabbit	LD50	oral	7mg/kg (7mg/kg)		Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1, 1966.
rabbit	LD50	skin	200mg/kg (200mg/kg)		Union Carbide Data Sheet. Vol. 6/18/1971,
rabbit	LDLo	subcutaneous	250mg/kg (250mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 43, Pg. 351, 1900.
rat	LC50	inhalation	18mg/m3/4H (18mg/m3)		Current Toxicology. Vol. 1, Pg. 47, 1993.
rat	LD50	intraperitoneal	4mg/kg (4mg/kg)		Toxicology and Applied Pharmacology. Vol. 71, Pg. 84, 1983.
rat	LD50	oral	26mg/kg (26mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 58(10), Pg. 4, 1993.
rat	LD50	subcutaneous	50mg/kg (50mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC LIVER: FATTY LIVER DEGERATION	Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.

 

Consensus Reports：

 

SAFETY PROFILE：

 Acrolein (CAS NO.107-02-8) is a severe pulmonary irritant and lachrymatory agent. Skin exposure to acrolein causes serious damage. Acrolein concentrations of 2 ppm are immediately harmful. It is not a suspected human carcinogen; no studies proved carcinogenic effects of acrolein on humans, but studies on rats have shown an increase in cancerous tumors from ingestion, but not from inhalation.  In October 2006, researchers found connections between Acrolein in the smoke from TOBACCO cigarettes and the risk of lung cancer. Furthermore, it is a toxic metabolite of Cyclophosphamide, a cytotoxic chemotherapy agent, and results in hemorrhagic cystitis .
Hazard Codes: F; T+,T;  N
Risk Statements: 11-24/25-26-34-50
11:  Highly Flammable 
24/25:  Toxic in contact with skin and if swallowed 
26:  Very Toxic by inhalation 
34:  Causes burns 
50:  Very Toxic to aquatic organisms
Safety Statements:  23-26-28-36/37/39-45-61
23:  Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) 
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
61:  Avoid release to the environment. Refer to special instructions safety data sheet
RIDADR UN 1092 6.1/PG 1
WGK Germany: 3
RTECS: AS1050000
F: 8-9
HazardClass: 6.1
PackingGroup: I

Standards and Recommendations：

 

Analytical Methods：