CAS No.:15942-05-9

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intraperitoneal	125mg/kg (125mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
dog	LD50	oral	500mg/kg (500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
guinea pig	LD50	intraperitoneal	280mg/kg (280mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
guinea pig	LD50	oral	1180mg/kg (1180mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
mouse	LD50	intraperitoneal	268mg/kg (268mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
mouse	LD50	intravenous	138mg/kg (138mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
mouse	LD50	oral	2380mg/kg (2380mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
mouse	LD50	subcutaneous	1060mg/kg (1060mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981.
rabbit	LD50	intravenous	64mg/kg (64mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rabbit	LD50	oral	2597mg/kg (2597mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rabbit	LDLo	intraperitoneal	400mg/kg (400mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
rat	LD50	intraperitoneal	262mg/kg (262mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: PERITONITIS	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rat	LD50	intravenous	100mg/kg (100mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rat	LD50	oral	4203mg/kg (4203mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981.
rat	LD50	subcutaneous	1489mg/kg (1489mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn
Risk Statements: 22 
R22: Harmful if swallowed
Safety Statements: 36 
S36: Wear suitable protective clothing
WGK Germany: 3
RTECS: GV8423000

Standards and Recommendations：

 

Analytical Methods：