CAS No.:26787-78-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	300mg/kg (300mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: HEMATURIA KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Clinical Pediatrics Vol. 32, Pg. 735, 1993.
child	TDLo	oral	682mg/kg (682mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED KIDNEY, URETER, AND BLADDER: HEMATURIA	Clinical Pediatrics Vol. 32, Pg. 735, 1993.
man	TDLo	oral	7143ug/kg (7.143mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Allergy. Vol. 52(Suppl,
man	TDLo	oral	40mg/kg/4D (40mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES	Lancet. Vol. 2, Pg. 707, 1978.
mouse	LD50	intracrebral	> 500mg/kg (500mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS	Chemotherapy Vol. 26, Pg. 196, 1980.
mouse	LD50	intraperitoneal	3590mg/kg (3590mg/kg)		Drugs in Japan Vol. -, Pg. 59, 1990.
mouse	LD50	oral	> 25gm/kg (25000mg/kg)		Drugs in Japan Vol. 6, Pg. 38, 1982.
mouse	LD50	subcutaneous	> 20mg/kg (20mg/kg)		Drugs in Japan Vol. -, Pg. 59, 1990.
rat	LD50	intraperitoneal	2870mg/kg (2870mg/kg)		Drugs in Japan Vol. -, Pg. 59, 1990.
rat	LD50	oral	> 15gm/kg (15000mg/kg)		Drugs in Japan Vol. 6, Pg. 38, 1982.
rat	LD50	subcutaneous	> 8gm/kg (8000mg/kg)		Drugs in Japan Vol. -, Pg. 59, 1990.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes : Xn,Xi
Risk Statements : 42/43 
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements : 22-36/37 
S22:Do not breathe dust. 
S36/37:Wear suitable protective clothing and gloves.
WGK Germany : 2
RTECS : XH8300000

Standards and Recommendations：

Purity of amoxicillin: 98.00%

Analytical Methods：