CAS No.:58-08-2

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	316mg/kg (316mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat	LDLo	intraperitoneal	180mg/kg (180mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.
cat	LDLo	intravenous	80mg/kg (80mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.
cat	LDLo	oral	100mg/kg (100mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.
cat	LDLo	subcutaneous	150mg/kg (150mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.
child	LDLo	oral	320mg/kg (320mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Forensic Science. Vol. 3, Pg. 275, 1974.
child	TDLo	oral	140mg/kg (140mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BLOOD: HEMORRHAGE	Pediatric Emergency Care. Vol. 10, Pg. 349, 1994.
dog	LD50	oral	140mg/kg (140mg/kg)		Drugs in Japan Vol. 6, Pg. 174, 1982.
dog	LD50	subcutaneous	100mg/kg (100mg/kg)		Drugs in Japan Vol. 6, Pg. 174, 1982.
dog	LDLo	intravenous	4mg/kg (4mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.
frog	LDLo	parenteral	120mg/kg (120mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: STIFFNESS CARDIAC: OTHER CHANGES	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 166, Pg. 437, 1932.
frog	LDLo	subcutaneous	120mg/kg (120mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 15, Pg. 331, 1959.
guinea pig	LD50	oral	230mg/kg (230mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Toxicology and Applied Pharmacology. Vol. 2, Pg. 23, 1960.
guinea pig	LDLo	intraperitoneal	220mg/kg (220mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.
guinea pig	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.
hamster	LD50	oral	230mg/kg (230mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Toxicology and Applied Pharmacology. Vol. 44, Pg. 1, 1978.
human	LDLo	oral	192mg/kg (192mg/kg)		Journal of New Drugs. Vol. 5, Pg. 252, 1965.
human	TDLo	intravenous	7mg/kg (7mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Acta Pharmacologica et Toxicologica. Vol. 15, Pg. 331, 1959.
infant	TDLo	intramuscular	36mg/kg (36mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	American Journal of Diseases of Children. Vol. 134, Pg. 495, 1980.
infant	TDLo	intravenous	68mg/kg (68mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	American Journal of Diseases of Children. Vol. 134, Pg. 495, 1980.
infant	TDLo	oral	14700ug/kg (14.7mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Clinical Biochemistry Vol. 10, Pg. 148, 1977.
man	TDLo	oral	13mg/kg (13mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS	American Journal of Psychiatry. Vol. 143, Pg. 1320, 1986.
man	TDLo	oral	51mg/kg (51mg/kg)	CARDIAC: CHANGE IN RATE KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" MUSCULOSKELETAL: TUMORS	Annals of Emergency Medicine. Vol. 18, Pg. 94, 1989.
mouse	LD50	intraperitoneal	168mg/kg (168mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: AGGRESSION KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Chemical and Pharmaceutical Bulletin. Vol. 22, Pg. 1459, 1974.
mouse	LD50	intravenous	62mg/kg (62mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Toxicology Letters. Vol. 29, Pg. 25, 1985.
mouse	LD50	oral	127mg/kg (127mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Toxicology and Applied Pharmacology. Vol. 44, Pg. 1, 1978.
mouse	LD50	subcutaneous	242mg/kg (242mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 601, 1956.
mouse	LD50	unreported	251mg/kg (251mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 2S, 1957.
pigeon	LDLo	subcutaneous	140mg/kg (140mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 1, Pg. 572, 1910.
rabbit	LD50	intravenous	58mg/kg (58mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.
rabbit	LD50	oral	224mg/kg (224mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Toxicology and Applied Pharmacology. Vol. 44, Pg. 1, 1978.
rabbit	LDLo	intramuscular	200mg/kg (200mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 1, Pg. 572, 1910.
rabbit	LDLo	intraperitoneal	150mg/kg (150mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1335, 1935.
rabbit	LDLo	subcutaneous	275mg/kg (275mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 1, Pg. 572, 1910.
rat	LD50	intraperitoneal	240mg/kg (240mg/kg)		Zeitschrift fuer Ernaehrungswissenschaft. Vol. 15, Pg. 64, 1976.
rat	LD50	intravenous	105mg/kg (105mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: STRUCTURAL OR FUNCTIONAL CHANGES IN URETER	Journal of Pharmacology and Experimental Therapeutics. Vol. 82, Pg. 89, 1944.
rat	LD50	oral	192mg/kg (192mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES BEHAVIORAL: WITHDRAWAL KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS	Journal of New Drugs. Vol. 5, Pg. 252, 1965.
rat	LD50	rectal	300mg/kg (300mg/kg)		Journal of Clinical Pharmacology and Journal of New Drugs. Vol. 7, Pg. 131, 1967.
rat	LD50	subcutaneous	170mg/kg (170mg/kg)		Journal of Clinical Pharmacology and Journal of New Drugs. Vol. 7, Pg. 131, 1967.
women	LDLo	intravenous	57mg/kg (57mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Acta Pharmacologica et Toxicologica. Vol. 15, Pg. 331, 1959.
women	LDLo	oral	400mg/kg (400mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Veterinary and Human Toxicology. Vol. 39, Pg. 228, 1997.
women	LDLo	oral	1gm/kg (1000mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Bulletin of the International Association of Forensic Toxicologists.Vol. -, Pg. 6, 1973.
women	TDLo	oral	96mg/kg/1D-I (96mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: TOXIC PSYCHOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Journal of Pediatrics. Vol. 105, Pg. 493, 1984.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn,T
Risk Statements : 22-25
R22:  Harmful if swallowed 
R25:  Toxic if swallowed 
Safety Statements : 16-36/37-45
S16:  Keep away from sources of ignition - No smoking 
S36/37:  Wear suitable protective clothing and gloves 
S45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
RIDADR : UN 1544 6.1/PG 3
WGK Germany : 1
F 10: Keep under argon.
HazardClass : 6.1
PackingGroup : III
RTECS : EV6475000

Standards and Recommendations：

 

Analytical Methods：